Benefits and challenges in using sero-prevalence data to inform models for measles and rubella elimination.
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Authors
Winter, A KMartinez, M E
Cutts, F T
Moss, W J
Ferrari, M
McKee, A
Lessler, J
Hayford, K
Wallinga, J
Metcalf, C J E
Type
ArticleLanguage
en
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Benefits and challenges in using sero-prevalence data to inform models for measles and rubella elimination.Published in
J Infect Dis 2018; 218(3):355-64Publiekssamenvatting
Control efforts for measles and rubella are intensifying globally. It becomes increasingly important to identify and reach remaining susceptible populations as elimination is approached. Serological surveys for measles and rubella can potentially measure susceptibility directly, but their use remains rare. Here, using simulations, we outline key subtleties in interpretation associated with the dynamic context of age-specific immunity, highlighting how the patterns of immunity predicted from disease surveillance and vaccination coverage data may be misleading. High quality representative sero-surveys could provide a more accurate assessment of immunity if challenges of conducting, analyzing, and interpreting them are overcome. We frame the core disease control and elimination questions that could be addressed by improved serological tools, discussing challenges and suggesting approaches to increase the feasibility and sustainability of the tool. Accounting for the dynamical context, sero-surveys could play a key role in efforts to achieve and sustain elimination.PMID
29562334ae974a485f413a2113503eed53cd6c53
10.1093/infdis/jiy137
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