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dc.contributor.authorTalsness, Chris E
dc.contributor.authorPenders, John
dc.contributor.authorJansen, Eugène H J M
dc.contributor.authorDamoiseaux, Jan
dc.contributor.authorThijs, Carel
dc.contributor.authorMommers, Monique
dc.date.accessioned2018-04-04T07:55:23Z
dc.date.available2018-04-04T07:55:23Z
dc.date.issued2017
dc.identifier.citationInfluence of vitamin D on key bacterial taxa in infant microbiota in the KOALA Birth Cohort Study. 2017, 12 (11):e0188011 PLoS ONEen
dc.identifier.issn1932-6203
dc.identifier.pmid29121673
dc.identifier.doi10.1371/journal.pone.0188011
dc.identifier.urihttp://hdl.handle.net/10029/621740
dc.description.abstractVitamin D has immunomodulatory properties giving it the potential to affect microbial colonization of the intestinal tract. We investigated whether maternal vitamin D supplemention, maternal plasma 25-hydroxyvitamin D concentration, or direct supplementation of the infant influences key bacterial taxa within microbiota of one month old infants. Infant and maternal vitamin D supplement use was ascertained via questionnaires. Maternal plasma 25-hydroxyvitamin D was determined at approximately the 36th week of pregnancy. In 913 one month old infants in the prospective KOALA Birth Cohort Study, fecal Bifidobacterium spp., Escherichia coli, Clostridium difficile, Bacteroides fragilis group, Lactobacillus spp. and total bacteria were quantified with real-time polymerase chain reaction assays targeting 16S rRNA gene sequences. The association between vitamin D exposure and prevalence or abundance of a specific bacterial group or species was analyzed using logistic or linear regression, respectively. There was a statistically significant negative linear trend between counts of Bifidobacterium spp. and levels of maternal vitamin D supplementation and maternal 25-hydroxyvitamin D quintiles, respectively. In addition, a positive linear trend between quintile groups and B. fragilis group counts was observed. Lower counts of C. difficile were associated with vitamin D supplementation of breast fed infants whose mothers were more likely to adhere to an alternative lifestyle in terms of, e.g., dietary habits. These data suggest that vitamin D influences the abundance of several key bacterial taxa within the infant microbiota. Given that intestinal microbiotic homeostasis may be an important factor in the prevention of immune mediated diseases and that vitamin D status is a modifiable factor, further investigation of the impact of postnatal vitamin D supplementation should be conducted in older infants.
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen
dc.subject.meshBacteria
dc.subject.meshDNA, Bacterial
dc.subject.meshDNA, Ribosomal
dc.subject.meshFeces
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant, Newborn
dc.subject.meshLogistic Models
dc.subject.meshMicrobiota
dc.subject.meshPregnancy
dc.subject.meshPregnancy Trimester, Third
dc.subject.meshProspective Studies
dc.subject.meshRNA, Ribosomal, 16S
dc.subject.meshVitamin D
dc.titleInfluence of vitamin D on key bacterial taxa in infant microbiota in the KOALA Birth Cohort Study.en
dc.typeArticleen
dc.identifier.journalPlos One 2017; 12(11):e0188011en
refterms.dateFOA2018-12-18T14:18:04Z
html.description.abstractVitamin D has immunomodulatory properties giving it the potential to affect microbial colonization of the intestinal tract. We investigated whether maternal vitamin D supplemention, maternal plasma 25-hydroxyvitamin D concentration, or direct supplementation of the infant influences key bacterial taxa within microbiota of one month old infants. Infant and maternal vitamin D supplement use was ascertained via questionnaires. Maternal plasma 25-hydroxyvitamin D was determined at approximately the 36th week of pregnancy. In 913 one month old infants in the prospective KOALA Birth Cohort Study, fecal Bifidobacterium spp., Escherichia coli, Clostridium difficile, Bacteroides fragilis group, Lactobacillus spp. and total bacteria were quantified with real-time polymerase chain reaction assays targeting 16S rRNA gene sequences. The association between vitamin D exposure and prevalence or abundance of a specific bacterial group or species was analyzed using logistic or linear regression, respectively. There was a statistically significant negative linear trend between counts of Bifidobacterium spp. and levels of maternal vitamin D supplementation and maternal 25-hydroxyvitamin D quintiles, respectively. In addition, a positive linear trend between quintile groups and B. fragilis group counts was observed. Lower counts of C. difficile were associated with vitamin D supplementation of breast fed infants whose mothers were more likely to adhere to an alternative lifestyle in terms of, e.g., dietary habits. These data suggest that vitamin D influences the abundance of several key bacterial taxa within the infant microbiota. Given that intestinal microbiotic homeostasis may be an important factor in the prevention of immune mediated diseases and that vitamin D status is a modifiable factor, further investigation of the impact of postnatal vitamin D supplementation should be conducted in older infants.


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