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dc.contributor.authorBuesen, Roland
dc.contributor.authorChorley, Brian N
dc.contributor.authorda Silva Lima, Beatriz
dc.contributor.authorDaston, George
dc.contributor.authorDeferme, Lize
dc.contributor.authorEbbels, Timothy
dc.contributor.authorGant, Timothy W
dc.contributor.authorGoetz, Amber
dc.contributor.authorGreally, John
dc.contributor.authorGribaldo, Laura
dc.contributor.authorHackermüller, Jörg
dc.contributor.authorHubesch, Bruno
dc.contributor.authorJennen, Danyel
dc.contributor.authorJohnson, Kamin
dc.contributor.authorKanno, Jun
dc.contributor.authorKauffmann, Hans-Martin
dc.contributor.authorLaffont, Madeleine
dc.contributor.authorMcMullen, Patrick
dc.contributor.authorMeehan, Richard
dc.contributor.authorPemberton, Mark
dc.contributor.authorPerdichizzi, Stefania
dc.contributor.authorPiersma, Aldert H
dc.contributor.authorSauer, Ursula G
dc.contributor.authorSchmidt, Kerstin
dc.contributor.authorSeitz, Hervé
dc.contributor.authorSumida, Kayo
dc.contributor.authorTollefsen, Knut E
dc.contributor.authorTong, Weida
dc.contributor.authorTralau, Tewes
dc.contributor.authorvan Ravenzwaay, Ben
dc.contributor.authorWeber, Ralf J M
dc.contributor.authorWorth, Andrew
dc.contributor.authorYauk, Carole
dc.contributor.authorPoole, Alan
dc.date.accessioned2018-04-04T09:31:08Z
dc.date.available2018-04-04T09:31:08Z
dc.date.issued2017-12
dc.identifier.citationApplying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop. 2017, 91 Suppl 1:S3-S13 Regul. Toxicol. Pharmacol.en
dc.identifier.issn1096-0295
dc.identifier.pmid28958911
dc.identifier.doi10.1016/j.yrtph.2017.09.002
dc.identifier.urihttp://hdl.handle.net/10029/621745
dc.description.abstractPrevailing knowledge gaps in linking specific molecular changes to apical outcomes and methodological uncertainties in the generation, storage, processing, and interpretation of 'omics data limit the application of 'omics technologies in regulatory toxicology. Against this background, the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) convened a workshop Applying 'omics technologies in chemicals risk assessment that is reported herein. Ahead of the workshop, multi-expert teams drafted frameworks on best practices for (i) a Good-Laboratory Practice-like context for collecting, storing and curating 'omics data; (ii) the processing of 'omics data; and (iii) weight-of-evidence approaches for integrating 'omics data. The workshop participants confirmed the relevance of these Frameworks to facilitate the regulatory applicability and use of 'omics data, and the workshop discussions provided input for their further elaboration. Additionally, the key objective (iv) to establish approaches to connect 'omics perturbations to phenotypic alterations was addressed. Generally, it was considered promising to strive to link gene expression changes and pathway perturbations to the phenotype by mapping them to specific adverse outcome pathways. While further work is necessary before gene expression changes can be used to establish safe levels of substance exposure, the ECETOC workshop provided important incentives towards achieving this goal.
dc.language.isoenen
dc.rightsArchived with thanks to Regulatory toxicology and pharmacology : RTPen
dc.titleApplying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop.en
dc.typeArticleen
dc.identifier.journalRegul Toxicol Pharmacol 2017; 91 (Suppl 1):3-13en
refterms.dateFOA2018-12-18T14:18:16Z
html.description.abstractPrevailing knowledge gaps in linking specific molecular changes to apical outcomes and methodological uncertainties in the generation, storage, processing, and interpretation of 'omics data limit the application of 'omics technologies in regulatory toxicology. Against this background, the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) convened a workshop Applying 'omics technologies in chemicals risk assessment that is reported herein. Ahead of the workshop, multi-expert teams drafted frameworks on best practices for (i) a Good-Laboratory Practice-like context for collecting, storing and curating 'omics data; (ii) the processing of 'omics data; and (iii) weight-of-evidence approaches for integrating 'omics data. The workshop participants confirmed the relevance of these Frameworks to facilitate the regulatory applicability and use of 'omics data, and the workshop discussions provided input for their further elaboration. Additionally, the key objective (iv) to establish approaches to connect 'omics perturbations to phenotypic alterations was addressed. Generally, it was considered promising to strive to link gene expression changes and pathway perturbations to the phenotype by mapping them to specific adverse outcome pathways. While further work is necessary before gene expression changes can be used to establish safe levels of substance exposure, the ECETOC workshop provided important incentives towards achieving this goal.


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