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dc.contributor.authorRasmussen, Kirsten
dc.contributor.authorRauscher, Hubert
dc.contributor.authorMech, Agnieszka
dc.contributor.authorRiego Sintes, Juan
dc.contributor.authorGilliland, Douglas
dc.contributor.authorGonzález, Mar
dc.contributor.authorKearns, Peter
dc.contributor.authorMoss, Kenneth
dc.contributor.authorVisser, Maaike
dc.contributor.authorGroenewold, Monique
dc.contributor.authorBleeker, Eric A J
dc.date.accessioned2018-04-04T09:34:31Z
dc.date.available2018-04-04T09:34:31Z
dc.date.issued2018-02
dc.identifier.citationPhysico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme. 2018, 92:8-28 Regul. Toxicol. Pharmacol.en
dc.identifier.issn1096-0295
dc.identifier.pmid29074277
dc.identifier.doi10.1016/j.yrtph.2017.10.019
dc.identifier.urihttp://hdl.handle.net/10029/621746
dc.description.abstractIdentifying and characterising nanomaterials require additional information on physico-chemical properties and test methods, compared to chemicals in general. Furthermore, regulatory decisions for chemicals are usually based upon certain toxicological properties, and these effects may not be equivalent to those for nanomaterials. However, regulatory agencies lack an authoritative decision framework for nanomaterials that links the relevance of certain physico-chemical endpoints to toxicological effects. This paper investigates various physico-chemical endpoints and available test methods that could be used to produce such a decision framework for nanomaterials. It presents an overview of regulatory relevance and methods used for testing fifteen proposed physico-chemical properties of eleven nanomaterials in the OECD Working Party on Manufactured Nanomaterials' Testing Programme, complemented with methods from literature, and assesses the methods' adequacy and applications limits. Most endpoints are of regulatory relevance, though the specific parameters depend on the nanomaterial and type of assessment. Size (distribution) is the common characteristic of all nanomaterials and is decisive information for classifying a material as a nanomaterial. Shape is an important particle descriptor. The octanol-water partitioning coefficient is undefined for particulate nanomaterials. Methods, including sample preparation, need to be further standardised, and some new methods are needed. The current work of OECD's Test Guidelines Programme regarding physico-chemical properties is highlighted.
dc.language.isoenen
dc.rightsArchived with thanks to Regulatory toxicology and pharmacology : RTPen
dc.titlePhysico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme.en
dc.typeArticleen
dc.identifier.journalRegul Toxicol Pharmacol 2018; 92:8-28en
refterms.dateFOA2018-12-18T14:18:22Z
html.description.abstractIdentifying and characterising nanomaterials require additional information on physico-chemical properties and test methods, compared to chemicals in general. Furthermore, regulatory decisions for chemicals are usually based upon certain toxicological properties, and these effects may not be equivalent to those for nanomaterials. However, regulatory agencies lack an authoritative decision framework for nanomaterials that links the relevance of certain physico-chemical endpoints to toxicological effects. This paper investigates various physico-chemical endpoints and available test methods that could be used to produce such a decision framework for nanomaterials. It presents an overview of regulatory relevance and methods used for testing fifteen proposed physico-chemical properties of eleven nanomaterials in the OECD Working Party on Manufactured Nanomaterials' Testing Programme, complemented with methods from literature, and assesses the methods' adequacy and applications limits. Most endpoints are of regulatory relevance, though the specific parameters depend on the nanomaterial and type of assessment. Size (distribution) is the common characteristic of all nanomaterials and is decisive information for classifying a material as a nanomaterial. Shape is an important particle descriptor. The octanol-water partitioning coefficient is undefined for particulate nanomaterials. Methods, including sample preparation, need to be further standardised, and some new methods are needed. The current work of OECD's Test Guidelines Programme regarding physico-chemical properties is highlighted.


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