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    IP-10 Kinetics in the First Week of Therapy are Strongly Associated with Bacteriological Confirmation of Tuberculosis Diagnosis in HIV-Infected Patients.

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    Authors
    García-Basteiro, Alberto L
    Mambuque, Edson
    den Hertog, Alice
    Saavedra, Belén
    Cuamba, Inocencia
    Oliveras, Laura
    Blanco, Silvia
    Bulo, Helder
    Brew, Joe
    Cuevas, Luis E
    Cobelens, Frank
    Nhabomba, Augusto
    Anthony, Richard
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    Type
    Article
    Language
    en
    
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    Title
    IP-10 Kinetics in the First Week of Therapy are Strongly Associated with Bacteriological Confirmation of Tuberculosis Diagnosis in HIV-Infected Patients.
    Published in
    Scie Rep 2017; 7(1):14302
    Publiekssamenvatting
    Simple effective tools to monitor the long treatment of tuberculosis (TB) are lacking. Easily measured host derived biomarkers have been identified but need to be validated in larger studies and different population groups. Here we investigate the early response in IP-10 levels (between day 0 and day 7 of TB therapy) to identify bacteriological status at diagnosis among 127 HIV-infected patients starting TB treatment. All participants were then classified as responding or not responding to treatment blindly using a previously described IP-10 kinetic algorithm. There were 77 bacteriologically confirmed cases and 41 Xpert MTB/RIF® and culture negative cases. Most participants had a measurable decline in IP-10 during the first 7 days of therapy. Bacteriologically confirmed cases were more likely to have high IP-10 levels at D0 and had a steeper decline than clinically diagnosed cases (mean decline difference 2231 pg/dl, 95% CI: 897-3566, p = 0.0013). Bacteriologically confirmed cases were more likely to have a measurable decline in IP-10 at day 7 than clinically diagnosed cases (48/77 (62.3%) vs 13/41 (31.7%), p < 0.001). This study confirms the association between a decrease in IP-10 levels during the first week of treatment and a bacteriological confirmation at diagnosis in a large cohort of HIV positive patients.
    DOI
    10.1038/s41598-017-13785-3
    PMID
    29084992
    URI
    http://hdl.handle.net/10029/621748
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-017-13785-3
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