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    A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening.

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    Authors
    van den Berg, Rosa
    Kooijman, Sander
    Noordam, Raymond
    Ramkisoensing, Ashna
    Abreu-Vieira, Gustavo
    Tambyrajah, Lauren L
    Dijk, Wieneke
    Ruppert, Philip
    Mol, Isabel M
    Kramar, Barbara
    Caputo, Rosanna
    Puig, Laura Sardón
    de Ruiter, Evelien M
    Kroon, Jan
    Hoekstra, Menno
    van der Sluis, Ronald J
    Meijer, Onno C
    Willems van Dijk, Ko
    van Kerkhof, Linda W M
    Christodoulides, Constantinos
    Karpe, Fredrik
    Gerhart-Hines, Zachary
    Kersten, Sander
    Meijer, Johanna H
    Coomans, Claudia P
    van Heemst, Diana
    Biermasz, Nienke R
    Rensen, Patrick C N
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    Type
    Article
    Language
    en
    
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    Title
    A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening.
    Published in
    Cell Rep 2018; 22(13):3521-33
    Publiekssamenvatting
    Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity.
    DOI
    10.1016/j.celrep.2018.03.004
    PMID
    29590620
    URI
    http://hdl.handle.net/10029/621806
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.celrep.2018.03.004
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