A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening.
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Authors
van den Berg, RosaKooijman, Sander
Noordam, Raymond
Ramkisoensing, Ashna
Abreu-Vieira, Gustavo
Tambyrajah, Lauren L
Dijk, Wieneke
Ruppert, Philip
Mol, Isabel M
Kramar, Barbara
Caputo, Rosanna
Puig, Laura Sardón
de Ruiter, Evelien M
Kroon, Jan
Hoekstra, Menno
van der Sluis, Ronald J
Meijer, Onno C
Willems van Dijk, Ko
van Kerkhof, Linda W M
Christodoulides, Constantinos
Karpe, Fredrik
Gerhart-Hines, Zachary
Kersten, Sander
Meijer, Johanna H
Coomans, Claudia P
van Heemst, Diana
Biermasz, Nienke R
Rensen, Patrick C N
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ArticleLanguage
en
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A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening.Published in
Cell Rep 2018; 22(13):3521-33Publiekssamenvatting
Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity.PMID
29590620ae974a485f413a2113503eed53cd6c53
10.1016/j.celrep.2018.03.004
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