Epidemiological links between tuberculosis cases identified twice as efficiently by whole genome sequencing than conventional molecular typing: A population-based study.
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Authors
Jajou, RanaNeeling, Albert de
Hunen, Rianne van
Vries, Gerard de
Schimmel, Henrieke
Mulder, Arnout
Anthony, Richard
Hoek, Wim van der
Soolingen, Dick van
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ArticleLanguage
en
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Epidemiological links between tuberculosis cases identified twice as efficiently by whole genome sequencing than conventional molecular typing: A population-based study.Published in
Plos One 2018; 13(4):e0195413Publiekssamenvatting
Patients with Mycobacterium tuberculosis isolates sharing identical DNA fingerprint patterns can be epidemiologically linked. However, municipal health services in the Netherlands are able to confirm an epidemiological link in only around 23% of the patients with isolates clustered by the conventional variable number of tandem repeat (VNTR) genotyping. This research aims to investigate whether whole genome sequencing (WGS) is a more reliable predictor of epidemiological links between tuberculosis patients than VNTR genotyping.PMID
29617456ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0195413
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