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    Epidemiological links between tuberculosis cases identified twice as efficiently by whole genome sequencing than conventional molecular typing: A population-based study.

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    Authors
    Jajou, Rana
    Neeling, Albert de
    Hunen, Rianne van
    Vries, Gerard de
    Schimmel, Henrieke
    Mulder, Arnout
    Anthony, Richard
    Hoek, Wim van der
    Soolingen, Dick van
    Type
    Article
    Language
    en
    
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    Title
    Epidemiological links between tuberculosis cases identified twice as efficiently by whole genome sequencing than conventional molecular typing: A population-based study.
    Published in
    Plos One 2018; 13(4):e0195413
    Publiekssamenvatting
    Patients with Mycobacterium tuberculosis isolates sharing identical DNA fingerprint patterns can be epidemiologically linked. However, municipal health services in the Netherlands are able to confirm an epidemiological link in only around 23% of the patients with isolates clustered by the conventional variable number of tandem repeat (VNTR) genotyping. This research aims to investigate whether whole genome sequencing (WGS) is a more reliable predictor of epidemiological links between tuberculosis patients than VNTR genotyping.
    DOI
    10.1371/journal.pone.0195413
    PMID
    29617456
    URI
    http://hdl.handle.net/10029/621826
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0195413
    Scopus Count
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