Anti-Müllerian Hormone Trajectories Are Associated With Cardiovascular Disease in Women: Results From the Doetinchem Cohort Study.

de Kat, Annelien C; Verschuren, W Monique; Eijkemans, Marinus J C; Broekmans, Frank J M; van der Schouw, Yvonne T

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Authors

de Kat, Annelien C
Verschuren, W Monique
Eijkemans, Marinus J C
Broekmans, Frank J M
van der Schouw, Yvonne T

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Article

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Title

Anti-Müllerian Hormone Trajectories Are Associated With Cardiovascular Disease in Women: Results From the Doetinchem Cohort Study.

Published in

Circulation 2017; 135(6):556-65

Publiekssamenvatting

Earlier age at menopause is widely considered to be associated with an increased risk of cardiovascular disease. However, the underlying mechanisms of this relationship remain undetermined. Indications suggest that anti-Müllerian hormone (AMH), an ovarian reserve marker, plays a physiological role outside of the reproductive system. Therefore, we investigated whether longitudinal AMH decline trajectories are associated with an increased risk of cardiovascular disease (CVD) occurrence.