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    Association between genotype and drug resistance profiles of Mycobacterium tuberculosis strains circulating in China in a national drug resistance survey.

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    Authors
    Zhou, Yang
    van den Hof, Susan
    Wang, Shengfen
    Pang, Yu
    Zhao, Bing
    Xia, Hui
    Anthony, Richard
    Ou, Xichao
    Li, Qiang
    Zheng, Yang
    Song, Yuanyuan
    Zhao, Yanlin
    van Soolingen, Dick
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    Type
    Article
    Language
    en
    
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    Title
    Association between genotype and drug resistance profiles of Mycobacterium tuberculosis strains circulating in China in a national drug resistance survey.
    Published in
    Plos One 2017; 12(3):e174197
    Publiekssamenvatting
    We describe the population structure of a representative collection of 3,133 Mycobacterium tuberculosis isolates, collected within the framework of a national resistance survey from 2007 in China. Genotyping data indicate that the epidemic strains in China can be divided into seven major complexes, of which 92% belonged to the East Asian (mainly Beijing strains) or the Euro-American lineage. The epidemic Beijing strains in China are closely related to the Beijing B0/W148 strain earlier described in Russia and a large cluster of these strains has spread national wide. The density of Beijing strains is high in the whole of China (average 70%), but the highest prevalence was found North of the Yellow river. The Euro-American lineage consists of three sublineages (sublineage_1, 2, and 3) and is more prevalent in the South. Beijing lineage showed the highest cluster rate of 48% and a significantly higher level of resistance to rifampicin (14%, p<0.001), ethambutol (9%, p = 0.001), and ofloxacin (5%, p = 0.011). Within the Euro-American Lineage, sublineage_3 revealed the highest cluster rate (28%) and presented a significantly elevated level of resistance to streptomycin (44%, p<0.001). Our findings suggest that standardised treatment in this region may have contributed to the successful spread of certain strains: sublineage_3 in the Euro-American lineage may have thrived when streptomycin was used without rifampicin for treatment, while later under DOTS based treatment, in which rifampicin plays a key role, Beijing lineage appears to be spreading.
    DOI
    10.1371/journal.pone.0174197
    PMID
    28333978
    URI
    http://hdl.handle.net/10029/621873
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0174197
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