Association between genotype and drug resistance profiles of Mycobacterium tuberculosis strains circulating in China in a national drug resistance survey.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
van den Hof, Susan
van Soolingen, Dick
MetadataShow full item record
TitleAssociation between genotype and drug resistance profiles of Mycobacterium tuberculosis strains circulating in China in a national drug resistance survey.
Published inPlos One 2017; 12(3):e174197
PubliekssamenvattingWe describe the population structure of a representative collection of 3,133 Mycobacterium tuberculosis isolates, collected within the framework of a national resistance survey from 2007 in China. Genotyping data indicate that the epidemic strains in China can be divided into seven major complexes, of which 92% belonged to the East Asian (mainly Beijing strains) or the Euro-American lineage. The epidemic Beijing strains in China are closely related to the Beijing B0/W148 strain earlier described in Russia and a large cluster of these strains has spread national wide. The density of Beijing strains is high in the whole of China (average 70%), but the highest prevalence was found North of the Yellow river. The Euro-American lineage consists of three sublineages (sublineage_1, 2, and 3) and is more prevalent in the South. Beijing lineage showed the highest cluster rate of 48% and a significantly higher level of resistance to rifampicin (14%, p<0.001), ethambutol (9%, p = 0.001), and ofloxacin (5%, p = 0.011). Within the Euro-American Lineage, sublineage_3 revealed the highest cluster rate (28%) and presented a significantly elevated level of resistance to streptomycin (44%, p<0.001). Our findings suggest that standardised treatment in this region may have contributed to the successful spread of certain strains: sublineage_3 in the Euro-American lineage may have thrived when streptomycin was used without rifampicin for treatment, while later under DOTS based treatment, in which rifampicin plays a key role, Beijing lineage appears to be spreading.
- [Population structure analysis of Mycobacterium tuberculosis Beijing family in Japan].
- Authors: Iwamoto T
- Issue date: 2009 Dec
- Correlations between drug resistance of Beijing/W lineage clinical isolates of Mycobacterium tuberculosis and sublineages: a 2009-2013 prospective study in Xinjiang province, China.
- Authors: Wang XH, Ma AG, Han XX, Gu XM, Fu LP, Li PG, Li FY, Wang QZ, Liang H, Katar A, Wang LJ
- Issue date: 2015 May 7
- Early ancient sublineages of Mycobacterium tuberculosis Beijing genotype: unexpected clues from phylogenomics of the pathogen and human history.
- Authors: Mokrousov I, Vyazovaya A, Pasechnik O, Gerasimova A, Dymova M, Chernyaeva E, Tatarintseva M, Stasenko V
- Issue date: 2019 Aug
- Associations between Mycobacterium tuberculosis Beijing genotype and drug resistance to four first-line drugs: a survey in China.
- Authors: Liu H, Zhang Y, Liu Z, Liu J, Hauck Y, Liu J, Dong H, Liu J, Zhao X, Lu B, Jiang Y, Vergnaud G, Pourcel C, Wan K
- Issue date: 2018 Feb
- Comparison of the socio-demographic and clinical features of pulmonary TB patients infected with sub-lineages within the W-Beijing and non-Beijing Mycobacterium tuberculosis.
- Authors: Hu Y, Mathema B, Zhao Q, Zheng X, Li D, Jiang W, Wang W, Xu B
- Issue date: 2016 Mar