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dc.contributor.authorZhou, Yang
dc.contributor.authorvan den Hof, Susan
dc.contributor.authorWang, Shengfen
dc.contributor.authorPang, Yu
dc.contributor.authorZhao, Bing
dc.contributor.authorXia, Hui
dc.contributor.authorAnthony, Richard
dc.contributor.authorOu, Xichao
dc.contributor.authorLi, Qiang
dc.contributor.authorZheng, Yang
dc.contributor.authorSong, Yuanyuan
dc.contributor.authorZhao, Yanlin
dc.contributor.authorvan Soolingen, Dick
dc.date.accessioned2018-04-30T11:22:08Z
dc.date.available2018-04-30T11:22:08Z
dc.date.issued2017
dc.identifier.citationAssociation between genotype and drug resistance profiles of Mycobacterium tuberculosis strains circulating in China in a national drug resistance survey. 2017, 12 (3):e0174197 PLoS ONEen
dc.identifier.issn1932-6203
dc.identifier.pmid28333978
dc.identifier.doi10.1371/journal.pone.0174197
dc.identifier.urihttp://hdl.handle.net/10029/621873
dc.description.abstractWe describe the population structure of a representative collection of 3,133 Mycobacterium tuberculosis isolates, collected within the framework of a national resistance survey from 2007 in China. Genotyping data indicate that the epidemic strains in China can be divided into seven major complexes, of which 92% belonged to the East Asian (mainly Beijing strains) or the Euro-American lineage. The epidemic Beijing strains in China are closely related to the Beijing B0/W148 strain earlier described in Russia and a large cluster of these strains has spread national wide. The density of Beijing strains is high in the whole of China (average 70%), but the highest prevalence was found North of the Yellow river. The Euro-American lineage consists of three sublineages (sublineage_1, 2, and 3) and is more prevalent in the South. Beijing lineage showed the highest cluster rate of 48% and a significantly higher level of resistance to rifampicin (14%, p<0.001), ethambutol (9%, p = 0.001), and ofloxacin (5%, p = 0.011). Within the Euro-American Lineage, sublineage_3 revealed the highest cluster rate (28%) and presented a significantly elevated level of resistance to streptomycin (44%, p<0.001). Our findings suggest that standardised treatment in this region may have contributed to the successful spread of certain strains: sublineage_3 in the Euro-American lineage may have thrived when streptomycin was used without rifampicin for treatment, while later under DOTS based treatment, in which rifampicin plays a key role, Beijing lineage appears to be spreading.
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen
dc.subject.meshAntitubercular Agents
dc.subject.meshChina
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshMicrobial Sensitivity Tests
dc.subject.meshMinisatellite Repeats
dc.subject.meshMycobacterium tuberculosis
dc.subject.meshRifampin
dc.subject.meshStreptomycin
dc.subject.meshSurveys and Questionnaires
dc.subject.meshTuberculosis, Multidrug-Resistant
dc.titleAssociation between genotype and drug resistance profiles of Mycobacterium tuberculosis strains circulating in China in a national drug resistance survey.en
dc.typeArticleen
dc.identifier.journalPlos One 2017; 12(3):e174197en
html.description.abstractWe describe the population structure of a representative collection of 3,133 Mycobacterium tuberculosis isolates, collected within the framework of a national resistance survey from 2007 in China. Genotyping data indicate that the epidemic strains in China can be divided into seven major complexes, of which 92% belonged to the East Asian (mainly Beijing strains) or the Euro-American lineage. The epidemic Beijing strains in China are closely related to the Beijing B0/W148 strain earlier described in Russia and a large cluster of these strains has spread national wide. The density of Beijing strains is high in the whole of China (average 70%), but the highest prevalence was found North of the Yellow river. The Euro-American lineage consists of three sublineages (sublineage_1, 2, and 3) and is more prevalent in the South. Beijing lineage showed the highest cluster rate of 48% and a significantly higher level of resistance to rifampicin (14%, p<0.001), ethambutol (9%, p = 0.001), and ofloxacin (5%, p = 0.011). Within the Euro-American Lineage, sublineage_3 revealed the highest cluster rate (28%) and presented a significantly elevated level of resistance to streptomycin (44%, p<0.001). Our findings suggest that standardised treatment in this region may have contributed to the successful spread of certain strains: sublineage_3 in the Euro-American lineage may have thrived when streptomycin was used without rifampicin for treatment, while later under DOTS based treatment, in which rifampicin plays a key role, Beijing lineage appears to be spreading.


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