Estimation of age-specific rates of reactivation and immune boosting of the varicella zoster virus.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
TitleEstimation of age-specific rates of reactivation and immune boosting of the varicella zoster virus.
Published inEpidemics 2017; 19:1-12
PubliekssamenvattingStudies into the impact of vaccination against the varicella zoster virus (VZV) have increasingly focused on herpes zoster (HZ), which is believed to be increasing in vaccinated populations with decreasing infection pressure. This idea can be traced back to Hope-Simpson's hypothesis, in which a person's immune status determines the likelihood that he/she will develop HZ. Immunity decreases over time, and can be boosted by contact with a person experiencing varicella (exogenous boosting) or by a reactivation attempt of the virus (endogenous boosting). Here we use transmission models to estimate age-specific rates of reactivation and immune boosting, exogenous as well as endogenous, using zoster incidence data from the Netherlands (2002-2011, n=7026). The boosting and reactivation rates are estimated with splines, enabling these quantities to be optimally informed by the data. The analyses show that models with high levels of exogenous boosting and estimated or zero endogenous boosting, constant rate of loss of immunity, and reactivation rate increasing with age (to more than 5% per year in the elderly) give the best fit to the data. Estimates of the rates of immune boosting and reactivation are strongly correlated. This has important implications as these parameters determine the fraction of the population with waned immunity. We conclude that independent evidence on rates of immune boosting and reactivation in persons with waned immunity are needed to robustly predict the impact of varicella vaccination on the incidence of HZ.
- The impact of childhood varicella vaccination on the incidence of herpes zoster in the general population: modelling the effect of exogenous and endogenous varicella-zoster virus immunity boosting.
- Authors: Sauboin C, Holl K, Bonanni P, Gershon AA, Benninghoff B, Carryn S, Burgess MA, Wutzler P
- Issue date: 2019 Feb 6
- Distribution of Health Effects and Cost-effectiveness of Varicella Vaccination are Shaped by the Impact on Herpes Zoster.
- Authors: van Lier A, Lugnér A, Opstelten W, Jochemsen P, Wallinga J, Schellevis F, Sanders E, de Melker H, van Boven M
- Issue date: 2015 Oct
- Point-Counterpoint: The Hope-Simpson Hypothesis and Its Implications Regarding an Effect of Routine Varicella Vaccination on Herpes Zoster Incidence.
- Authors: Harpaz R, van Hoek AJ
- Issue date: 2018 Sep 22
- Projections of zoster incidence in Australia based on demographic and transmission models of varicella-zoster virus infection.
- Authors: Costantino V, Gidding HF, Wood JG
- Issue date: 2017 Dec 4
- The impact of 2-dose routine measles, mumps, rubella, and varicella vaccination in France on the epidemiology of varicella and zoster using a dynamic model with an empirical contact matrix.
- Authors: Ouwens MJ, Littlewood KJ, Sauboin C, Téhard B, Denis F, Boëlle PY, Alain S
- Issue date: 2015 Apr 1