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    Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis.

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    Authors
    Pasanen, Anu
    Karjalainen, Minna K
    Bont, Louis
    Piippo-Savolainen, Eija
    Ruotsalainen, Marja
    Goksör, Emma
    Kumawat, Kuldeep
    Hodemaekers, Hennie
    Nuolivirta, Kirsi
    Jartti, Tuomas
    Wennergren, Göran
    Hallman, Mikko
    Rämet, Mika
    Korppi, Matti
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    Article
    Language
    en
    
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    Title
    Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis.
    Published in
    Sci Rep 2017; 7:41653
    Publiekssamenvatting
    Bronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic background of bronchiolitis is not well characterized. To identify polymorphisms associated with bronchiolitis, we conducted a genome-wide association study (GWAS) in which 5,300,000 single nucleotide polymorphisms (SNPs) were tested for association in a Finnish-Swedish population of 217 children hospitalized for bronchiolitis and 778 controls. The most promising SNPs (n = 77) were genotyped in a Dutch replication population of 416 cases and 432 controls. Finally, we used a set of 202 Finnish bronchiolitis cases to further investigate candidate SNPs. We did not detect genome-wide significant associations, but several suggestive association signals (p < 10-5) were observed in the GWAS. In the replication population, three SNPs were nominally associated (p < 0.05). Of them, rs269094 was an expression quantitative trait locus (eQTL) for KCND3, previously shown to be associated with occupational asthma. In the additional set of Finnish cases, the association for another SNP (rs9591920) within a noncoding RNA locus was further strengthened. Our results provide a first genome-wide examination of the genetics underlying bronchiolitis. These preliminary findings require further validation in a larger sample size.
    DOI
    10.1038/srep41653
    PMID
    28139761
    URI
    http://hdl.handle.net/10029/621881
    ae974a485f413a2113503eed53cd6c53
    10.1038/srep41653
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