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    Intermediate Susceptibility Dose-Dependent Breakpoints For High Dose Rifampicin, Isoniazid and Pyrazinamide Treatment in multidrug-resistant tuberculosis Programmes.

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    Authors
    Zuur, Marlanka A
    Pasipanodya, Jotam G
    van Soolingen, Dick
    van der Werf, Tjip S
    Gumbo, Tawanda
    Alffenaar, Jan-Willem C
    Type
    Article
    Language
    en
    
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    Title
    Intermediate Susceptibility Dose-Dependent Breakpoints For High Dose Rifampicin, Isoniazid and Pyrazinamide Treatment in multidrug-resistant tuberculosis Programmes.
    Published in
    Clin Infect Dis 2018; 67(11):1743-9
    Publiekssamenvatting
    In infectious diseases, for some drugs, bacterial susceptibility is categorized as susceptible, intermediate-susceptible dose-dependent (ISDD), and resistant. The strategy is to use higher doses of first-line agents in the ISDD category, thereby preserving the use of these drugs. This system has not been applied to anti-tuberculosis drugs. Pharmacokinetics/pharmacodynamics (PK/PD) target exposures, in tandem with Monte Carlo experiments (MCE), recently identified susceptibility breakpoints of 0.0312 mg/L for isoniazid, 0.0625 mg/L for rifampicin, and 50 mg/L for pyrazinamide. These have been confirmed in clinical studies.
    DOI
    10.1093/cid/ciy346
    PMID
    29697766
    URI
    http://hdl.handle.net/10029/621893
    ae974a485f413a2113503eed53cd6c53
    10.1093/cid/ciy346
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