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    A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk.

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    Authors
    Murphy, Neil
    Achaintre, David
    Zamora-Ros, Raul
    Jenab, Mazda
    Boutron-Ruault, Marie-Christine
    Carbonnel, Franck
    Savoye, Isabelle
    Kaaks, Rudolf
    Kühn, Tilman
    Boeing, Heiner
    Aleksandrova, Krasimira
    Tjønneland, Anne
    Kyrø, Cecilie
    Overvad, Kim
    Quirós, J Ramón
    Sánchez, Maria-Jose
    Altzibar, Jone M
    María Huerta, José
    Barricarte, Aurelio
    Khaw, Kay-Tee
    Bradbury, Kathryn E
    Perez-Cornago, Aurora
    Trichopoulou, Antonia
    Karakatsani, Anna
    Peppa, Eleni
    Palli, Domenico
    Grioni, Sara
    Tumino, Rosario
    Sacerdote, Carlotta
    Panico, Salvatore
    Bueno-de-Mesquita, Bas
    Peeters, Petra H
    Rutegård, Martin
    Johansson, Ingegerd
    Freisling, Heinz
    Noh, Hwayoung
    Cross, Amanda J
    Vineis, Paolo
    Tsilidis, Kostas
    Gunter, Marc J
    Scalbert, Augustin
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    Type
    Article
    Language
    en
    
    Metadata
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    Title
    A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk.
    Published in
    Int J Cancer 2018; advance online publication (ahead of print)
    Publiekssamenvatting
    Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (qvalues ) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log2 -transformed multivariable models, equol (odds ratio [OR] per log2 -value, 0.86, 95% confidence interval [95%CI]=0.79-0.93; qvalue =0.01) and homovanillic acid (OR per log2 -value, 1.46, 95%CI=1.16-1.84; qvalue =0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR=0.61, 95%CI=0.41-0.91, ptrend =0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR=1.72, 95%CI=1.17-2.53, ptrend <0.0001). No heterogeneity for these associations was observed by sex and across other colon cancer risk factors. The remaining polyphenols were not associated with colon cancer risk. Higher equol concentrations were associated with lower risk, and higher homovanillic acid concentrations were associated with greater risk, of colon cancer. These findings support a potential role for specific polyphenols in colon tumorigenesis. This article is protected by copyright. All rights reserved.
    DOI
    10.1002/ijc.31563
    PMID
    29696648
    URI
    http://hdl.handle.net/10029/621895
    ae974a485f413a2113503eed53cd6c53
    10.1002/ijc.31563
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