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dc.contributor.authorMurphy, Neil
dc.contributor.authorAchaintre, David
dc.contributor.authorZamora-Ros, Raul
dc.contributor.authorJenab, Mazda
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorCarbonnel, Franck
dc.contributor.authorSavoye, Isabelle
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKühn, Tilman
dc.contributor.authorBoeing, Heiner
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorTjønneland, Anne
dc.contributor.authorKyrø, Cecilie
dc.contributor.authorOvervad, Kim
dc.contributor.authorQuirós, J Ramón
dc.contributor.authorSánchez, Maria-Jose
dc.contributor.authorAltzibar, Jone M
dc.contributor.authorMaría Huerta, José
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorBradbury, Kathryn E
dc.contributor.authorPerez-Cornago, Aurora
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorKarakatsani, Anna
dc.contributor.authorPeppa, Eleni
dc.contributor.authorPalli, Domenico
dc.contributor.authorGrioni, Sara
dc.contributor.authorTumino, Rosario
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorPanico, Salvatore
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorPeeters, Petra H
dc.contributor.authorRutegård, Martin
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorFreisling, Heinz
dc.contributor.authorNoh, Hwayoung
dc.contributor.authorCross, Amanda J
dc.contributor.authorVineis, Paolo
dc.contributor.authorTsilidis, Kostas
dc.contributor.authorGunter, Marc J
dc.contributor.authorScalbert, Augustin
dc.date.accessioned2018-05-04T09:15:54Z
dc.date.available2018-05-04T09:15:54Z
dc.date.issued2018-04-26
dc.identifier.citationA Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk. 2018 Int. J. Canceren
dc.identifier.issn1097-0215
dc.identifier.pmid29696648
dc.identifier.doi10.1002/ijc.31563
dc.identifier.urihttp://hdl.handle.net/10029/621895
dc.description.abstractPolyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (qvalues ) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log2 -transformed multivariable models, equol (odds ratio [OR] per log2 -value, 0.86, 95% confidence interval [95%CI]=0.79-0.93; qvalue =0.01) and homovanillic acid (OR per log2 -value, 1.46, 95%CI=1.16-1.84; qvalue =0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR=0.61, 95%CI=0.41-0.91, ptrend =0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR=1.72, 95%CI=1.17-2.53, ptrend <0.0001). No heterogeneity for these associations was observed by sex and across other colon cancer risk factors. The remaining polyphenols were not associated with colon cancer risk. Higher equol concentrations were associated with lower risk, and higher homovanillic acid concentrations were associated with greater risk, of colon cancer. These findings support a potential role for specific polyphenols in colon tumorigenesis. This article is protected by copyright. All rights reserved.
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.titleA Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk.en
dc.typeArticleen
dc.identifier.journalInt J Cancer 2018; advance online publication (ahead of print)en
html.description.abstractPolyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (qvalues ) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log2 -transformed multivariable models, equol (odds ratio [OR] per log2 -value, 0.86, 95% confidence interval [95%CI]=0.79-0.93; qvalue =0.01) and homovanillic acid (OR per log2 -value, 1.46, 95%CI=1.16-1.84; qvalue =0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR=0.61, 95%CI=0.41-0.91, ptrend =0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR=1.72, 95%CI=1.17-2.53, ptrend <0.0001). No heterogeneity for these associations was observed by sex and across other colon cancer risk factors. The remaining polyphenols were not associated with colon cancer risk. Higher equol concentrations were associated with lower risk, and higher homovanillic acid concentrations were associated with greater risk, of colon cancer. These findings support a potential role for specific polyphenols in colon tumorigenesis. This article is protected by copyright. All rights reserved.


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