Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE).
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Authors
Nagel, GabrieleStafoggia, Massimo
Pedersen, Marie
Andersen, Zorana J
Galassi, Claudia
Munkenast, Jule
Jaensch, Andrea
Sommar, Johan
Forsberg, Bertil
Olsson, David
Oftedal, Bente
Krog, Norun H
Aamodt, Geir
Pyko, Andrei
Pershagen, Göran
Korek, Michal
De Faire, Ulf
Pedersen, Nancy L
Östenson, Claes-Göran
Fratiglioni, Laura
Sørensen, Mette
Tjønneland, Anne
Peeters, Petra H
Bueno-de-Mesquita, Bas
Vermeulen, Roel
Eeftens, Marloes
Plusquin, Michelle
Key, Timothy J
Concin, Hans
Lang, Alois
Wang, Meng
Tsai, Ming-Yi
Grioni, Sara
Marcon, Alessandro
Krogh, Vittorio
Ricceri, Fulvio
Sacerdote, Carlotta
Ranzi, Andrea
Cesaroni, Giulia
Forastiere, Francesco
Tamayo-Uria, Ibon
Amiano, Pilar
Dorronsoro, Miren
de Hoogh, Kees
Beelen, Rob
Vineis, Paolo
Brunekreef, Bert
Hoek, Gerard
Raaschou-Nielsen, Ole
Weinmayr, Gudrun
Type
ArticleLanguage
en
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Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE).Published in
Int J Cancer 2018; 143(7):1632-43Publiekssamenvatting
Air pollution has been classified as carcinogenic to humans. However, to date little is known about the relevance for cancers of the stomach and upper aerodigestive tract (UADT). We investigated the association of long-term exposure to ambient air pollution with incidence of gastric and UADT cancer in 11 European cohorts. Air pollution exposure was assigned by land-use regression models for particulate matter (PM) below 10 µm (PM10 ), below 2.5 µm (PM2.5 ), between 2.5 and 10 µm (PMcoarse ), PM2.5 absorbance and nitrogen oxides (NO2 and NOX ) as well as approximated by traffic indicators. Cox regression models with adjustment for potential confounders were used for cohort-specific analyses. Combined estimates were determined with random effects meta-analyses. During average follow-up of 14.1 years of 305 551 individuals, 744 incident cases of gastric cancer and 933 of UADT cancer occurred. The hazard ratio for an increase of 5 µg/m3 of PM2.5 was 1.38 (95%-CI 0.99;1.92) for gastric and 1.05 (95%-CI 0.62;1.77) for UADT cancers. No associations were found for any of the other exposures considered. Adjustment for additional confounders and restriction to study participants with stable addresses did not influence markedly the effect estimate for PM2.5 and gastric cancer. Higher estimated risks of gastric cancer associated with PM2.5 was found in men (HR 1.98 (1.30;3.01)) as compared to women (HR 0.85 (0.5;1.45)). This large multicentre cohort study shows an association between long-term exposure to PM2.5 and gastric cancer, but not UADT cancers, suggesting that air pollution may contribute to gastric cancer risk. This article is protected by copyright. All rights reserved.PMID
29696642ae974a485f413a2113503eed53cd6c53
10.1002/ijc.31564
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