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dc.contributor.authorNagel, Gabriele
dc.contributor.authorStafoggia, Massimo
dc.contributor.authorPedersen, Marie
dc.contributor.authorAndersen, Zorana J
dc.contributor.authorGalassi, Claudia
dc.contributor.authorMunkenast, Jule
dc.contributor.authorJaensch, Andrea
dc.contributor.authorSommar, Johan
dc.contributor.authorForsberg, Bertil
dc.contributor.authorOlsson, David
dc.contributor.authorOftedal, Bente
dc.contributor.authorKrog, Norun H
dc.contributor.authorAamodt, Geir
dc.contributor.authorPyko, Andrei
dc.contributor.authorPershagen, Göran
dc.contributor.authorKorek, Michal
dc.contributor.authorDe Faire, Ulf
dc.contributor.authorPedersen, Nancy L
dc.contributor.authorÖstenson, Claes-Göran
dc.contributor.authorFratiglioni, Laura
dc.contributor.authorSørensen, Mette
dc.contributor.authorTjønneland, Anne
dc.contributor.authorPeeters, Petra H
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorVermeulen, Roel
dc.contributor.authorEeftens, Marloes
dc.contributor.authorPlusquin, Michelle
dc.contributor.authorKey, Timothy J
dc.contributor.authorConcin, Hans
dc.contributor.authorLang, Alois
dc.contributor.authorWang, Meng
dc.contributor.authorTsai, Ming-Yi
dc.contributor.authorGrioni, Sara
dc.contributor.authorMarcon, Alessandro
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorRanzi, Andrea
dc.contributor.authorCesaroni, Giulia
dc.contributor.authorForastiere, Francesco
dc.contributor.authorTamayo-Uria, Ibon
dc.contributor.authorAmiano, Pilar
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorde Hoogh, Kees
dc.contributor.authorBeelen, Rob
dc.contributor.authorVineis, Paolo
dc.contributor.authorBrunekreef, Bert
dc.contributor.authorHoek, Gerard
dc.contributor.authorRaaschou-Nielsen, Ole
dc.contributor.authorWeinmayr, Gudrun
dc.date.accessioned2018-05-04T09:18:27Z
dc.date.available2018-05-04T09:18:27Z
dc.date.issued2018-04-26
dc.identifier.citationAir pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE). 2018 Int. J. Canceren
dc.identifier.issn1097-0215
dc.identifier.pmid29696642
dc.identifier.doi10.1002/ijc.31564
dc.identifier.urihttp://hdl.handle.net/10029/621896
dc.description.abstractAir pollution has been classified as carcinogenic to humans. However, to date little is known about the relevance for cancers of the stomach and upper aerodigestive tract (UADT). We investigated the association of long-term exposure to ambient air pollution with incidence of gastric and UADT cancer in 11 European cohorts. Air pollution exposure was assigned by land-use regression models for particulate matter (PM) below 10 µm (PM10 ), below 2.5 µm (PM2.5 ), between 2.5 and 10 µm (PMcoarse ), PM2.5 absorbance and nitrogen oxides (NO2 and NOX ) as well as approximated by traffic indicators. Cox regression models with adjustment for potential confounders were used for cohort-specific analyses. Combined estimates were determined with random effects meta-analyses. During average follow-up of 14.1 years of 305 551 individuals, 744 incident cases of gastric cancer and 933 of UADT cancer occurred. The hazard ratio for an increase of 5 µg/m3 of PM2.5 was 1.38 (95%-CI 0.99;1.92) for gastric and 1.05 (95%-CI 0.62;1.77) for UADT cancers. No associations were found for any of the other exposures considered. Adjustment for additional confounders and restriction to study participants with stable addresses did not influence markedly the effect estimate for PM2.5 and gastric cancer. Higher estimated risks of gastric cancer associated with PM2.5 was found in men (HR 1.98 (1.30;3.01)) as compared to women (HR 0.85 (0.5;1.45)). This large multicentre cohort study shows an association between long-term exposure to PM2.5 and gastric cancer, but not UADT cancers, suggesting that air pollution may contribute to gastric cancer risk. This article is protected by copyright. All rights reserved.
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.titleAir pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE).en
dc.typeArticleen
dc.identifier.journalInt J Cancer 2018; 143(7):1632-43en
html.description.abstractAir pollution has been classified as carcinogenic to humans. However, to date little is known about the relevance for cancers of the stomach and upper aerodigestive tract (UADT). We investigated the association of long-term exposure to ambient air pollution with incidence of gastric and UADT cancer in 11 European cohorts. Air pollution exposure was assigned by land-use regression models for particulate matter (PM) below 10 µm (PM10 ), below 2.5 µm (PM2.5 ), between 2.5 and 10 µm (PMcoarse ), PM2.5 absorbance and nitrogen oxides (NO2 and NOX ) as well as approximated by traffic indicators. Cox regression models with adjustment for potential confounders were used for cohort-specific analyses. Combined estimates were determined with random effects meta-analyses. During average follow-up of 14.1 years of 305 551 individuals, 744 incident cases of gastric cancer and 933 of UADT cancer occurred. The hazard ratio for an increase of 5 µg/m3 of PM2.5 was 1.38 (95%-CI 0.99;1.92) for gastric and 1.05 (95%-CI 0.62;1.77) for UADT cancers. No associations were found for any of the other exposures considered. Adjustment for additional confounders and restriction to study participants with stable addresses did not influence markedly the effect estimate for PM2.5 and gastric cancer. Higher estimated risks of gastric cancer associated with PM2.5 was found in men (HR 1.98 (1.30;3.01)) as compared to women (HR 0.85 (0.5;1.45)). This large multicentre cohort study shows an association between long-term exposure to PM2.5 and gastric cancer, but not UADT cancers, suggesting that air pollution may contribute to gastric cancer risk. This article is protected by copyright. All rights reserved.


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