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dc.contributor.authorYe, Nan
dc.contributor.authorWang, Zhuang
dc.contributor.authorWang, Se
dc.contributor.authorPeijnenburg, Willie J G M
dc.date.accessioned2018-05-04T12:29:26Z
dc.date.available2018-05-04T12:29:26Z
dc.date.issued2018-04-14
dc.identifier.citationToxicity of mixtures of zinc oxide and graphene oxide nanoparticles to aquatic organisms of different trophic level: particles outperform dissolved ions. 2018:1-16 Nanotoxicologyen
dc.identifier.issn1743-5404
dc.identifier.pmid29658385
dc.identifier.doi10.1080/17435390.2018.1458342
dc.identifier.urihttp://hdl.handle.net/10029/621917
dc.description.abstractConcomitant releases of various engineered nanoparticles (NPs) into the environment have resulted in concerns regarding their combined toxicity to aquatic organisms. It is however, still elusive to distinguish the contribution to toxicity of components in NP mixtures. In the present study, we quantitatively evaluated the relative contribution of NPs in their particulate form (NP(particle)) and of dissolved ions released from NPs (NP(ion)) to the combined toxicity of binary mixtures of ZnO NPs and graphene oxide nanoplatelets (GO NPs) to three aquatic organisms of different trophic levels, including an alga species (Scenedesmus obliquus), a cladoceran species (Daphnia magna), and a freshwater fish larva (Danio rerio). Our results revealed that the effects of ZnO NPs and GO NPs were additive to S. obliquus and D. magna but antagonistic to D. rerio. The relative contribution to toxicity (RCT) of the mixture components to S. obliquus decreased in the order of RCTGO NP(particle) > RCTZnO NP(particle) > RCTZnO NP(ion), while the RCT of the mixture components to D. magna and D. rerio decreased in the order of RCTZnO NP(particle) > RCTGO NP(particle) > RCTZnO NP(ion). This finding also implies that the suspended particles rather than the dissolved Zn-ions dictated the combined toxicity of binary mixtures of ZnO NPs and GO NPs to the aquatic organisms of different trophic level. The alleviation of the contribution to toxicity of the ionic form of ZnO NPs was caused by the adsorption of the dissolved ions on GO NPs. Furthermore, the ZnO NP(particle) and GO NP(particle) displayed a different contribution to the observed mixture toxicity, dependent on the trophic level of the aquatic organisms tested. The difference of the contributions between the two particulate forms was mainly associated with differences in the intracellular accumulation of reactive oxygen species. Our findings highlight the important role of particles in the ecological impact of multi-nanomaterial systems.
dc.language.isoenen
dc.rightsArchived with thanks to Nanotoxicologyen
dc.titleToxicity of mixtures of zinc oxide and graphene oxide nanoparticles to aquatic organisms of different trophic level: particles outperform dissolved ions.en
dc.typeArticleen
dc.identifier.journalNanotoxicology 2018; advance online publication (ahead of print)en
html.description.abstractConcomitant releases of various engineered nanoparticles (NPs) into the environment have resulted in concerns regarding their combined toxicity to aquatic organisms. It is however, still elusive to distinguish the contribution to toxicity of components in NP mixtures. In the present study, we quantitatively evaluated the relative contribution of NPs in their particulate form (NP(particle)) and of dissolved ions released from NPs (NP(ion)) to the combined toxicity of binary mixtures of ZnO NPs and graphene oxide nanoplatelets (GO NPs) to three aquatic organisms of different trophic levels, including an alga species (Scenedesmus obliquus), a cladoceran species (Daphnia magna), and a freshwater fish larva (Danio rerio). Our results revealed that the effects of ZnO NPs and GO NPs were additive to S. obliquus and D. magna but antagonistic to D. rerio. The relative contribution to toxicity (RCT) of the mixture components to S. obliquus decreased in the order of RCTGO NP(particle) > RCTZnO NP(particle) > RCTZnO NP(ion), while the RCT of the mixture components to D. magna and D. rerio decreased in the order of RCTZnO NP(particle) > RCTGO NP(particle) > RCTZnO NP(ion). This finding also implies that the suspended particles rather than the dissolved Zn-ions dictated the combined toxicity of binary mixtures of ZnO NPs and GO NPs to the aquatic organisms of different trophic level. The alleviation of the contribution to toxicity of the ionic form of ZnO NPs was caused by the adsorption of the dissolved ions on GO NPs. Furthermore, the ZnO NP(particle) and GO NP(particle) displayed a different contribution to the observed mixture toxicity, dependent on the trophic level of the aquatic organisms tested. The difference of the contributions between the two particulate forms was mainly associated with differences in the intracellular accumulation of reactive oxygen species. Our findings highlight the important role of particles in the ecological impact of multi-nanomaterial systems.


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