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dc.contributor.authorRietman, M Liset
dc.contributor.authorSpijkerman, Annemieke M W
dc.contributor.authorWong, Albert
dc.contributor.authorvan Steeg, Harry
dc.contributor.authorBürkle, Alexander
dc.contributor.authorMoreno-Villanueva, María
dc.contributor.authorSindlinger, Thilo
dc.contributor.authorFranceschi, Claudio
dc.contributor.authorGrubeck-Loebenstein, Beatrix
dc.contributor.authorBernhardt, Jürgen
dc.contributor.authorSlagboom, P Eline
dc.contributor.authorToussaint, Olivier
dc.contributor.authorDebacq-Chainiaux, Florence
dc.contributor.authorSikora, Ewa
dc.contributor.authorGonos, Efstathios S
dc.contributor.authorBreusing, Nicolle
dc.contributor.authorStuetz, Wolfgang
dc.contributor.authorWeber, Daniela
dc.contributor.authorGrune, Tilman
dc.contributor.authorBasso, Andrea
dc.contributor.authorPiacenza, Francesco
dc.contributor.authorMalavolta, Marco
dc.contributor.authorCollino, Sebastiano
dc.contributor.authorJansen, Eugene H J M
dc.contributor.authorVerschuren, W M Monique
dc.contributor.authorDollé, Martijn E T
dc.date.accessioned2018-05-14T09:18:10Z
dc.date.available2018-05-14T09:18:10Z
dc.date.issued2018-04-29
dc.identifier.citationAntioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE Study. 2018 Mech. Ageing Dev.en
dc.identifier.issn1872-6216
dc.identifier.pmid29719199
dc.identifier.doi10.1016/j.mad.2018.04.007
dc.identifier.urihttp://hdl.handle.net/10029/621921
dc.description.abstractFrailty among elderly people leads to an increased risk for negative health outcomes. To prevent frailty, we need a better understanding of the underlying mechanisms and early detection of individuals at risk. Both may be served by identifying candidate (bio)markers, i.e. biomarkers and markers, for the physical, cognitive, and psychological frailty domains. We used univariate (Rank-ANOVA) and multivariate (elastic net) approaches on the RASIG study population (age range: 35-74 years, n = 2220) of the MARK-AGE Study to study up to 331 (bio)markers between individuals with and without frailty for each domain. Biomarkers and markers identified by both approaches were studied further regarding their association with frailty using logistic regression. Univariately, we found lower levels of antioxidants, including β-cryptoxanthin and zeaxanthin, in those who were physically, cognitively or psychologically frail. Additionally, self-reported health was worse in these three frail groups. Multivariately, we observed lower levels of β-cryptoxanthin and zeaxanthin in the cognitively frail. Levels of these carotenoids were inversely associated with the risk of being cognitively frail after adjusting for confounders. Antioxidants and self-reported health are potential (bio)markers to detect persons at risk of becoming frail. The biomarkers identified may indicate the involvement of inflammation in frailty, especially for physical and cognitive frailty.
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.titleAntioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE Study.en
dc.typeArticleen
dc.identifier.journalMech Ageing Dev 2019; 177:135-143en
html.description.abstractFrailty among elderly people leads to an increased risk for negative health outcomes. To prevent frailty, we need a better understanding of the underlying mechanisms and early detection of individuals at risk. Both may be served by identifying candidate (bio)markers, i.e. biomarkers and markers, for the physical, cognitive, and psychological frailty domains. We used univariate (Rank-ANOVA) and multivariate (elastic net) approaches on the RASIG study population (age range: 35-74 years, n = 2220) of the MARK-AGE Study to study up to 331 (bio)markers between individuals with and without frailty for each domain. Biomarkers and markers identified by both approaches were studied further regarding their association with frailty using logistic regression. Univariately, we found lower levels of antioxidants, including β-cryptoxanthin and zeaxanthin, in those who were physically, cognitively or psychologically frail. Additionally, self-reported health was worse in these three frail groups. Multivariately, we observed lower levels of β-cryptoxanthin and zeaxanthin in the cognitively frail. Levels of these carotenoids were inversely associated with the risk of being cognitively frail after adjusting for confounders. Antioxidants and self-reported health are potential (bio)markers to detect persons at risk of becoming frail. The biomarkers identified may indicate the involvement of inflammation in frailty, especially for physical and cognitive frailty.


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