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dc.contributor.authorBeekhuijzen, Manon
dc.contributor.authorSchneider, Steffen
dc.contributor.authorBarraclough, Narinder
dc.contributor.authorHallmark, Nina
dc.contributor.authorHoberman, Alan
dc.contributor.authorLordi, Sheri
dc.contributor.authorMoxon, Mary
dc.contributor.authorPerks, Deborah
dc.contributor.authorPiersma, Aldert H
dc.contributor.authorMakris, Susan L
dc.date.accessioned2018-05-15T09:31:42Z
dc.date.available2018-05-15T09:31:42Z
dc.date.issued2018-05-02
dc.identifier.citationThe urgency for optimization and harmonization of thyroid hormone analyses and their interpretation in developmental and reproductive toxicology studies. 2018 Reprod. Toxicol.en
dc.identifier.issn1873-1708
dc.identifier.pmid29729334
dc.identifier.doi10.1016/j.reprotox.2018.04.017
dc.identifier.urihttp://hdl.handle.net/10029/621948
dc.description.abstractIn recent years several OECD test guidelines have been updated and some will be updated shortly with the requirement to measure thyroid hormone levels in the blood of mammalian laboratory species. There is, however, an imperative need for clarification and guidance regarding the collection, assessment, and interpretation of thyroid hormone data for regulatory toxicology and risk assessment. Clarification and guidance is needed for 1) timing and methods of blood collection, 2) standardization and validation of the analytical methods, 3) triggers for additional measurements, 4) the need for T4 measurements in postnatal day (PND) 4 pups, and 5) the interpretation of changes in thyroid hormone levels regarding adversity. Discussions on these topics have already been initiated, and involve expert scientists from a number of international multisector organizations. This paper provides an overview of existing issues, current activities and recommendations for moving forward.
dc.language.isoenen
dc.rightsArchived with thanks to Reproductive toxicology (Elmsford, N.Y.)en
dc.titleThe urgency for optimization and harmonization of thyroid hormone analyses and their interpretation in developmental and reproductive toxicology studies.en
dc.typeArticleen
dc.identifier.journalReprod Toxicol 2018; advance online publication (ahead of print)en
html.description.abstractIn recent years several OECD test guidelines have been updated and some will be updated shortly with the requirement to measure thyroid hormone levels in the blood of mammalian laboratory species. There is, however, an imperative need for clarification and guidance regarding the collection, assessment, and interpretation of thyroid hormone data for regulatory toxicology and risk assessment. Clarification and guidance is needed for 1) timing and methods of blood collection, 2) standardization and validation of the analytical methods, 3) triggers for additional measurements, 4) the need for T4 measurements in postnatal day (PND) 4 pups, and 5) the interpretation of changes in thyroid hormone levels regarding adversity. Discussions on these topics have already been initiated, and involve expert scientists from a number of international multisector organizations. This paper provides an overview of existing issues, current activities and recommendations for moving forward.


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