Aging-related trajectories of lung function in the general population-The Doetinchem Cohort Study.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authorsvan Oostrom, Sandra H
Engelfriet, Peter M
Verschuren, W M Monique
Wouters, Inge M
Smit, Henriëtte A
Kerstjens, Huib A M
Picavet, H Susan J
MetadataShow full item record
TitleAging-related trajectories of lung function in the general population-The Doetinchem Cohort Study.
Published inPlos One 2018; 13(5):e0197250
PubliekssamenvattingThe objective of this study was to explore trajectories of lung function decline with age in the general population, and to study the effect of sociodemographic and life style related risk factors, in particular smoking and BMI. For this purpose, we used data from the Doetinchem Cohort Study (DCS) of men and women, selected randomly from the general population and aged 20-59 years at inclusion in 1987-1991, and followed until the present. Participants in the DCS are assessed every five years. Spirometry has been performed as part of this assessment from 1994 onwards. Participants were included in this study if spirometric measurement of FEV1, which in this study was the main parameter of interest, was acceptable and reproducible on at least one measurement round, leading to the inclusion of 5727 individuals (3008 females). Statistical analysis revealed three typical trajectories. The majority of participants followed a trajectory that closely adhered to the Global Lung Initiative Reference values (94.9% of men and 96.4% of women). Two other trajectories showed a more pronounced decline. Smoking and the presence of respiratory complaints were the best predictors of a trajectory with stronger decline. A greater BMI over the follow-up period was associated with a more unfavorable FEV1 course both in men (β = -0.027 (SD = 0.002); P < 0.001) and in women (β = -0.008 (SD = 0.001); P < 0.001). Smokers at baseline who quit the habit during follow-up, showed smaller decline in FEV1 in comparison to persistent smokers, independent of BMI change (In men β = -0.074 (SD = 0.020); P < 0.001. In women β = -0.277 (SD = 0.068); P < 0.001). In conclusion, three typical trajectories of age-related FEV1 decline could be distinguished. Change in the lifestyle related risk factors, BMI and smoking, significantly impact aging-related decline of lung function. Identifying deviant trajectories may help in early recognition of those at risk of a diagnosis of lung disease later in life.
The following license files are associated with this item:
- Creative Commons
- Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life.
- Authors: Bui DS, Lodge CJ, Burgess JA, Lowe AJ, Perret J, Bui MQ, Bowatte G, Gurrin L, Johns DP, Thompson BR, Hamilton GS, Frith PA, James AL, Thomas PS, Jarvis D, Svanes C, Russell M, Morrison SC, Feather I, Allen KJ, Wood-Baker R, Hopper J, Giles GG, Abramson MJ, Walters EH, Matheson MC, Dharmage SC
- Issue date: 2018 Jul
- The natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohort.
- Authors: Kohansal R, Martinez-Camblor P, Agustí A, Buist AS, Mannino DM, Soriano JB
- Issue date: 2009 Jul 1
- Lung function decline over 25 years of follow-up among black and white adults in the ARIC study cohort.
- Authors: Mirabelli MC, Preisser JS, Loehr LR, Agarwal SK, Barr RG, Couper DJ, Hankinson JL, Hyun N, Folsom AR, London SJ
- Issue date: 2016 Apr
- [The role of spirometry in encouraging smoking cessation in general practice. A pilot study using "lung age"].
- Authors: Lorenzo A, Noël F, Lorenzo M, Van Den Broucke J
- Issue date: 2017 Sep
- Comparing FEV1 in adults in two community-based studies.
- Authors: Xu X, Weiss ST, Dockery DW, Schouten JP, Rijcken B
- Issue date: 1995 Sep