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dc.contributor.authorvan Roekel, Eline H
dc.contributor.authorTrijsburg, Laura
dc.contributor.authorAssi, Nada
dc.contributor.authorCarayol, Marion
dc.contributor.authorAchaintre, David
dc.contributor.authorMurphy, Neil
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorSchmidt, Julie A
dc.contributor.authorStepien, Magdalena
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKühn, Tilman
dc.contributor.authorBoeing, Heiner
dc.contributor.authorIqbal, Khalid
dc.contributor.authorPalli, Domenico
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorTumino, Rosario
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorPanico, Salvatore
dc.contributor.authorPeeters, Petra H
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorArdanaz, Eva
dc.contributor.authorLujan-Barroso, Leila
dc.contributor.authorQuirós, J Ramón
dc.contributor.authorHuerta, José M
dc.contributor.authorMolina-Portillo, Elena
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorTsilidis, Konstantinos K
dc.contributor.authorRiboli, Elio
dc.contributor.authorRostgaard-Hansen, Agnetha Linn
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOvervad, Kim
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorKarakatsani, Anna
dc.contributor.authorKotanidou, Anastasia
dc.contributor.authorHåkansson, Anders
dc.contributor.authorMalm, Johan
dc.contributor.authorWeijenberg, Matty P
dc.contributor.authorGunter, Marc J
dc.contributor.authorJenab, Mazda
dc.contributor.authorJohansson, Mattias
dc.contributor.authorTravis, Ruth C
dc.contributor.authorScalbert, Augustin
dc.contributor.authorFerrari, Pietro
dc.date.accessioned2018-05-28T12:10:51Z
dc.date.available2018-05-28T12:10:51Z
dc.date.issued2018-05-22
dc.identifier.citationCirculating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort. 2018, 10 (5) Nutrientsen
dc.identifier.issn2072-6643
dc.identifier.pmid29789452
dc.identifier.doi10.3390/nu10050654
dc.identifier.urihttp://hdl.handle.net/10029/621962
dc.description.abstractIdentifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTM p180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption with metabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value < 0.05) were further tested in the replication set (Bonferroni-corrected p-value < 0.05). Of the 72 metabolites significantly related to alcohol intake in the discovery set, 34 were also significant in the replication analysis, including three acylcarnitines, the amino acid citrulline, four lysophosphatidylcholines, 13 diacylphosphatidylcholines, seven acyl-alkylphosphatidylcholines, and six sphingomyelins. Our results confirmed earlier findings that alcohol consumption was associated with several lipid metabolites, and possibly also with specific acylcarnitines and amino acids. This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions.
dc.language.isoenen
dc.rightsArchived with thanks to Nutrientsen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleCirculating Metabolites Associated with Alcohol Intake in the European Prospective Investigation into Cancer and Nutrition Cohort.en
dc.typeArticleen
dc.identifier.journalNutrients 2018; 10(5):e654en
refterms.dateFOA2018-12-18T14:26:57Z
html.description.abstractIdentifying the metabolites associated with alcohol consumption may provide insights into the metabolic pathways through which alcohol may affect human health. We studied associations of alcohol consumption with circulating concentrations of 123 metabolites among 2974 healthy participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Alcohol consumption at recruitment was self-reported through dietary questionnaires. Metabolite concentrations were measured by tandem mass spectrometry (BIOCRATES AbsoluteIDQTM p180 kit). Data were randomly divided into discovery (2/3) and replication (1/3) sets. Multivariable linear regression models were used to evaluate confounder-adjusted associations of alcohol consumption with metabolite concentrations. Metabolites significantly related to alcohol intake in the discovery set (FDR q-value < 0.05) were further tested in the replication set (Bonferroni-corrected p-value < 0.05). Of the 72 metabolites significantly related to alcohol intake in the discovery set, 34 were also significant in the replication analysis, including three acylcarnitines, the amino acid citrulline, four lysophosphatidylcholines, 13 diacylphosphatidylcholines, seven acyl-alkylphosphatidylcholines, and six sphingomyelins. Our results confirmed earlier findings that alcohol consumption was associated with several lipid metabolites, and possibly also with specific acylcarnitines and amino acids. This provides further leads for future research studies aiming at elucidating the mechanisms underlying the effects of alcohol in relation to morbid conditions.


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