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dc.contributor.authorKinkar, Liina
dc.contributor.authorLaurimäe, Teivi
dc.contributor.authorAcosta-Jamett, Gerardo
dc.contributor.authorAndresiuk, Vanessa
dc.contributor.authorBalkaya, Ibrahim
dc.contributor.authorCasulli, Adriano
dc.contributor.authorGasser, Robin B
dc.contributor.authorvan der Giessen, Joke
dc.contributor.authorGonzález, Luis Miguel
dc.contributor.authorHaag, Karen L
dc.contributor.authorZait, Houria
dc.contributor.authorIrshadullah, Malik
dc.contributor.authorJabbar, Abdul
dc.contributor.authorJenkins, David J
dc.contributor.authorKia, Eshrat Beigom
dc.contributor.authorManfredi, Maria Teresa
dc.contributor.authorMirhendi, Hossein
dc.contributor.authorM'rad, Selim
dc.contributor.authorRostami-Nejad, Mohammad
dc.contributor.authorOudni-M'rad, Myriam
dc.contributor.authorPierangeli, Nora Beatriz
dc.contributor.authorPonce-Gordo, Francisco
dc.contributor.authorRehbein, Steffen
dc.contributor.authorSharbatkhori, Mitra
dc.contributor.authorSimsek, Sami
dc.contributor.authorSoriano, Silvia Viviana
dc.contributor.authorSprong, Hein
dc.contributor.authorŠnábel, Viliam
dc.contributor.authorUmhang, Gérald
dc.contributor.authorVarcasia, Antonio
dc.contributor.authorSaarma, Urmas
dc.date.accessioned2018-06-22T11:13:31Z
dc.date.available2018-06-22T11:13:31Z
dc.date.issued2018-05-19
dc.identifier.citationGlobal phylogeography and genetic diversity of the zoonotic tapeworm Echinococcus granulosus sensu stricto genotype G1. 2018 Int. J. Parasitol.en
dc.identifier.issn1879-0135
dc.identifier.pmid29782829
dc.identifier.doi10.1016/j.ijpara.2018.03.006
dc.identifier.urihttp://hdl.handle.net/10029/622009
dc.description.abstractEchinococcus granulosus sensu stricto (s.s.) is the major cause of human cystic echinococcosis worldwide and is listed among the most severe parasitic diseases of humans. To date, numerous studies have investigated the genetic diversity and population structure of E. granulosus s.s. in various geographic regions. However, there has been no global study. Recently, using mitochondrial DNA, it was shown that E. granulosus s.s. G1 and G3 are distinct genotypes, but a larger dataset is required to confirm the distinction of these genotypes. The objectives of this study were to: (i) investigate the distinction of genotypes G1 and G3 using a large global dataset; and (ii) analyse the genetic diversity and phylogeography of genotype G1 on a global scale using near-complete mitogenome sequences. For this study, 222 globally distributed E. granulosus s.s. samples were used, of which 212 belonged to genotype G1 and 10 to G3. Using a total sequence length of 11,682 bp, we inferred phylogenetic networks for three datasets: E. granulosus s.s. (n = 222), G1 (n = 212) and human G1 samples (n = 41). In addition, the Bayesian phylogenetic and phylogeographic analyses were performed. The latter yielded several strongly supported diffusion routes of genotype G1 originating from Turkey, Tunisia and Argentina. We conclude that: (i) using a considerably larger dataset than employed previously, E. granulosus s.s. G1 and G3 are indeed distinct mitochondrial genotypes; (ii) the genetic diversity of E. granulosus s.s. G1 is high globally, with lower values in South America; and (iii) the complex phylogeographic patterns emerging from the phylogenetic and geographic analyses suggest that the current distribution of genotype G1 has been shaped by intensive animal trade.
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.titleGlobal phylogeography and genetic diversity of the zoonotic tapeworm Echinococcus granulosus sensu stricto genotype G1.en
dc.typeArticleen
dc.identifier.journalInt J Parasitol 2018; advance online publication (ahead of print)en
html.description.abstractEchinococcus granulosus sensu stricto (s.s.) is the major cause of human cystic echinococcosis worldwide and is listed among the most severe parasitic diseases of humans. To date, numerous studies have investigated the genetic diversity and population structure of E. granulosus s.s. in various geographic regions. However, there has been no global study. Recently, using mitochondrial DNA, it was shown that E. granulosus s.s. G1 and G3 are distinct genotypes, but a larger dataset is required to confirm the distinction of these genotypes. The objectives of this study were to: (i) investigate the distinction of genotypes G1 and G3 using a large global dataset; and (ii) analyse the genetic diversity and phylogeography of genotype G1 on a global scale using near-complete mitogenome sequences. For this study, 222 globally distributed E. granulosus s.s. samples were used, of which 212 belonged to genotype G1 and 10 to G3. Using a total sequence length of 11,682 bp, we inferred phylogenetic networks for three datasets: E. granulosus s.s. (n = 222), G1 (n = 212) and human G1 samples (n = 41). In addition, the Bayesian phylogenetic and phylogeographic analyses were performed. The latter yielded several strongly supported diffusion routes of genotype G1 originating from Turkey, Tunisia and Argentina. We conclude that: (i) using a considerably larger dataset than employed previously, E. granulosus s.s. G1 and G3 are indeed distinct mitochondrial genotypes; (ii) the genetic diversity of E. granulosus s.s. G1 is high globally, with lower values in South America; and (iii) the complex phylogeographic patterns emerging from the phylogenetic and geographic analyses suggest that the current distribution of genotype G1 has been shaped by intensive animal trade.


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