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dc.contributor.authorLackenby, Angie
dc.contributor.authorBesselaar, Terry G
dc.contributor.authorDaniels, Rod S
dc.contributor.authorFry, Alicia
dc.contributor.authorGregory, Vicki
dc.contributor.authorGubareva, Larisa V
dc.contributor.authorHuang, Weijuan
dc.contributor.authorHurt, Aeron C
dc.contributor.authorLeang, Sook-Kwan
dc.contributor.authorLee, Raphael T C
dc.contributor.authorLo, Janice
dc.contributor.authorLollis, Lori
dc.contributor.authorMaurer-Stroh, Sebastian
dc.contributor.authorOdagiri, Takato
dc.contributor.authorPereyaslov, Dmitriy
dc.contributor.authorTakashita, Emi
dc.contributor.authorWang, Dayan
dc.contributor.authorZhang, Wenqing
dc.contributor.authorMeijer, Adam
dc.date.accessioned2018-08-02T13:07:39Z
dc.date.available2018-08-02T13:07:39Z
dc.date.issued2018-07-03
dc.identifier.citationGlobal update on the susceptibility of human influenza viruses to neuraminidase inhibitors and status of novel antivirals, 2016-2017. 2018, 157:38-46 Antiviral Res.en
dc.identifier.issn1872-9096
dc.identifier.pmid29981793
dc.identifier.doi10.1016/j.antiviral.2018.07.001
dc.identifier.urihttp://hdl.handle.net/10029/622103
dc.description.abstractA total of 13672 viruses, collected by World Health Organization recognised National Influenza Centres between May 2016 and May 2017, were assessed for neuraminidase inhibitor susceptibility by four WHO Collaborating Centres for Reference and Research on Influenza and one WHO Collaborating Centre for the Surveillance Epidemiology and Control of Influenza. The 50% inhibitory concentration (IC50) was determined for oseltamivir and zanamivir for all viruses, and for peramivir and laninamivir in a subset (n = 8457). Of the viruses tested, 94% were obtained from the Western Pacific, Americas and European WHO regions, while limited viruses were available from the Eastern Mediterranean, African and South East Asian regions. Reduced inhibition (RI) by one or more neuraminidase inhibitor was exhibited by 0.2% of viruses tested (n = 32). The frequency of viruses with RI has remained low since this global analysis began (2015/16: 0.8%, 2014/15: 0.5%; 2013/14: 1.9%; 2012/13: 0.6%) but 2016/17 has the lowest frequency observed to date. Analysis of 13581 neuraminidase sequences retrieved from public databases, of which 5243 sequences were from viruses not included in the phenotypic analyses, identified 58 further viruses (29 without phenotypic analyses) with amino acid substitutions associated with RI by at least one neuraminidase inhibitor. Bringing the total proportion to 0.5% (90/18915). This 2016/17 analysis demonstrates that neuraminidase inhibitors remain suitable for treatment and prophylaxis of influenza virus infections, but continued monitoring is important. An expansion of surveillance testing is paramount since several novel influenza antivirals are in late stage clinical trials with some resistance already having been identified.
dc.language.isoenen
dc.rightsArchived with thanks to Antiviral researchen
dc.titleGlobal update on the susceptibility of human influenza viruses to neuraminidase inhibitors and status of novel antivirals, 2016-2017.en
dc.typeArticleen
dc.identifier.journalAntiviral Res 2018; 157:38-46en
html.description.abstractA total of 13672 viruses, collected by World Health Organization recognised National Influenza Centres between May 2016 and May 2017, were assessed for neuraminidase inhibitor susceptibility by four WHO Collaborating Centres for Reference and Research on Influenza and one WHO Collaborating Centre for the Surveillance Epidemiology and Control of Influenza. The 50% inhibitory concentration (IC50) was determined for oseltamivir and zanamivir for all viruses, and for peramivir and laninamivir in a subset (n = 8457). Of the viruses tested, 94% were obtained from the Western Pacific, Americas and European WHO regions, while limited viruses were available from the Eastern Mediterranean, African and South East Asian regions. Reduced inhibition (RI) by one or more neuraminidase inhibitor was exhibited by 0.2% of viruses tested (n = 32). The frequency of viruses with RI has remained low since this global analysis began (2015/16: 0.8%, 2014/15: 0.5%; 2013/14: 1.9%; 2012/13: 0.6%) but 2016/17 has the lowest frequency observed to date. Analysis of 13581 neuraminidase sequences retrieved from public databases, of which 5243 sequences were from viruses not included in the phenotypic analyses, identified 58 further viruses (29 without phenotypic analyses) with amino acid substitutions associated with RI by at least one neuraminidase inhibitor. Bringing the total proportion to 0.5% (90/18915). This 2016/17 analysis demonstrates that neuraminidase inhibitors remain suitable for treatment and prophylaxis of influenza virus infections, but continued monitoring is important. An expansion of surveillance testing is paramount since several novel influenza antivirals are in late stage clinical trials with some resistance already having been identified.


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