• Login
    View Item 
    •   Home
    • RIVM official reports
    • RIVM official reports
    • View Item
    •   Home
    • RIVM official reports
    • RIVM official reports
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of WARPCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherDepartmentThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherDepartment

    My Account

    LoginRegister

    Statistics

    Display statistics

    Mixture exposure to PFAS: A Relative Potency Factor approach

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    2018-0070.pdf
    Size:
    1.059Mb
    Format:
    PDF
    Download
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Authors
    Zeilmaker MJ
    Fragki S
    Verbruggen EMJ
    Bokkers BGH
    Lijzen JPA
    Series/Report no.
    RIVM report 2018-0070
    Type
    Onderzoeksrapport
    Language
    en
    
    Metadata
    Show full item record
    Title
    Mixture exposure to PFAS: A Relative Potency Factor approach
    Translated Title
    Gecombineerde blootstelling aan PFAS: een benadering met factoren voor relatieve potentie
    Publiekssamenvatting
    PFAS is a large group of poly- and perfluoroalkyl compounds. They have a dirt-repellent effect and are therefore used, for example, in finishing clothing. For the best known PFAS, PFOA and PFOS, much information is available about the properties have been researched, as have the quantity people may be exposed to without causing negative effects on health. In 2016, RIVM derived such a quantity for PFOA. However, much less is known about most of the other compounds in this group of substances. PFASs often occur together as contamination in soil, groundwater or drinking water. To be able to better assess the risks of this type of contamination, the RIVM has investigated the extent to which it is possible to express the harmfulness of a number of PFASs in relation to PFOA. It was concluded that this can be done by using so-called Relative Potency Factors (RPFs). Here the exposure to a PFAS mixture is expressed as a comparable amount of PFOA. This method can be used for dealing with pollution with PFASs in the environment, e.g. in cases involving contamination in soil, groundwater or drinking water. Measured PFAS quantities are simply expressed in PFOA units, so that they can be compared with PFOA standards for soil or (drinking) water. The use of the RPF method does, however, have an important condition, namely that a (limited) set of comparable toxicity data for individual PFAS compounds is available. For the relevant health effect (on the liver of test animals), such information was available for 11 PFAS compounds. This effect has been investigated, because the liver reacts most sensitively to PFOA in humans and laboratory animals. The effect is an enlargement of the liver (hypertrophy). This is an unwanted effect.
    Publisher
    Rijksinstituut voor Volksgezondheid en Milieu RIVM
    Sponsors
    gemeente Dordrecht
    DOI
    10.21945/RIVM-2018-0070
    URI
    http://hdl.handle.net/10029/622164
    ae974a485f413a2113503eed53cd6c53
    10.21945/RIVM-2018-0070
    Scopus Count
    Collections
    RIVM official reports

    entitlement

     

    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.