Current EU research activities on combined exposure to multiple chemicals.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsBopp, Stephanie K
Dalla Costa, Silvia
Dorne, Jean-Lou C M
Drakvik, Paula E
Karjalainen, Tuomo K
van Klaveren, Jacob
Tarazona, Jose V
van de Water, Bob
van Gils, Jos
MetadataShow full item record
TitleCurrent EU research activities on combined exposure to multiple chemicals.
Published inEnviron Int 2018; 120:544-562
PubliekssamenvattingHumans and wildlife are exposed to an intractably large number of different combinations of chemicals via food, water, air, consumer products, and other media and sources. This raises concerns about their impact on public and environmental health. The risk assessment of chemicals for regulatory purposes mainly relies on the assessment of individual chemicals. If exposure to multiple chemicals is considered in a legislative framework, it is usually limited to chemicals falling within this framework and co-exposure to chemicals that are covered by a different regulatory framework is often neglected. Methodologies and guidance for assessing risks from combined exposure to multiple chemicals have been developed for different regulatory sectors, however, a harmonised, consistent approach for performing mixture risk assessments and management across different regulatory sectors is lacking. At the time of this publication, several EU research projects are running, funded by the current European Research and Innovation Programme Horizon 2020 or the Seventh Framework Programme. They aim at addressing knowledge gaps and developing methodologies to better assess chemical mixtures, by generating and making available internal and external exposure data, developing models for exposure assessment, developing tools for in silico and in vitro effect assessment to be applied in a tiered framework and for grouping of chemicals, as well as developing joint epidemiological-toxicological approaches for mixture risk assessment and for prioritising mixtures of concern. The projects EDC-MixRisk, EuroMix, EUToxRisk, HBM4EU and SOLUTIONS have started an exchange between the consortia, European Commission Services and EU Agencies, in order to identify where new methodologies have become available and where remaining gaps need to be further addressed. This paper maps how the different projects contribute to the data needs and assessment methodologies and identifies remaining challenges to be further addressed for the assessment of chemical mixtures.
- Overview on legislation and scientific approaches for risk assessment of combined exposure to multiple chemicals: the potential EuroMix contribution.
- Authors: Rotter S, Beronius A, Boobis AR, Hanberg A, van Klaveren J, Luijten M, Machera K, Nikolopoulou D, van der Voet H, Zilliacus J, Solecki R
- Issue date: 2018 Oct
- Regulatory assessment and risk management of chemical mixtures: challenges and ways forward.
- Authors: Bopp SK, Kienzler A, Richarz AN, van der Linden SC, Paini A, Parissis N, Worth AP
- Issue date: 2019 Feb
- Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment.
- Authors: Drakvik E, Altenburger R, Aoki Y, Backhaus T, Bahadori T, Barouki R, Brack W, Cronin MTD, Demeneix B, Hougaard Bennekou S, van Klaveren J, Kneuer C, Kolossa-Gehring M, Lebret E, Posthuma L, Reiber L, Rider C, Rüegg J, Testa G, van der Burg B, van der Voet H, Warhurst AM, van de Water B, Yamazaki K, Öberg M, Bergman Å
- Issue date: 2020 Jan
- Recommendations for international harmonisation, implementation and further development of suitable scientific approaches regarding the assessment of mixture effects.
- Authors: Fischer BC, Rotter S, Schubert J, Marx-Stoelting P, Solecki R
- Issue date: 2020 Jul
- Methodology for health risk assessment of combined exposures to multiple chemicals.
- Authors: Beronius A, Zilliacus J, Hanberg A, Luijten M, van der Voet H, van Klaveren J
- Issue date: 2020 Sep