Dietary folate intake and pancreatic cancer risk: Results from the European Prospective Investigation into Cancer and Nutrition.
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Authors
Park, Jin YoungBueno-de-Mesquita, H Bas
Ferrari, Pietro
Weiderpass, Elisabete
de Batlle, Jordi
Tjønneland, Anne
Kyro, Cecilie
Rebours, Vinciane
Boutron-Ruault, Marie-Christine
Mancini, Francesca Romana
Katzke, Verena
Kühn, Tilman
Boeing, Heiner
Trichopoulou, Antonia
La Vecchia, Carlo
Kritikou, Maria
Masala, Giovanna
Pala, Valeria
Tumino, Rosario
Panico, Salvatore
Peeters, Petra H
Skeie, Guri
Merino, Susana
Duell, Eric J
Rodríguez-Barranco, Miguel
Dorronsoro, Miren
Chirlaque, Maria-Dolores
Ardanaz, Eva
Gylling, Björn
Schneede, Jörn
Ericson, Ulrika
Sternby, Hanna
Khaw, Kay-Tee
Bradbury, Kathryn E
Huybrechts, Inge
Aune, Dagfinn
Vineis, Paolo
Slimani, Nadia
Type
ArticleLanguage
en
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Dietary folate intake and pancreatic cancer risk: Results from the European Prospective Investigation into Cancer and Nutrition.Published in
Int J Cancer 2019; 144(7):1511-21Publiekssamenvatting
Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/d) compared with the lowest (<241 μg/d) was 0.81 (95% CI: 0.51, 1.31; Ptrend = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles (HR=4.42 (95% CI: 1.05, 18.62) for ≥353 μg/d vs. <241 μg/d, Ptrend = 0.01). Nonetheless, there was no significant interaction between smoking and dietary folate intake (Pinteraction = 0.99). We found no association between dietary folate intake and PC risk in this large European study. This article is protected by copyright. All rights reserved.PMID
30178496ae974a485f413a2113503eed53cd6c53
10.1002/ijc.31830
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