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    Dietary folate intake and pancreatic cancer risk: Results from the European Prospective Investigation into Cancer and Nutrition.

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    Authors
    Park, Jin Young
    Bueno-de-Mesquita, H Bas
    Ferrari, Pietro
    Weiderpass, Elisabete
    de Batlle, Jordi
    Tjønneland, Anne
    Kyro, Cecilie
    Rebours, Vinciane
    Boutron-Ruault, Marie-Christine
    Mancini, Francesca Romana
    Katzke, Verena
    Kühn, Tilman
    Boeing, Heiner
    Trichopoulou, Antonia
    La Vecchia, Carlo
    Kritikou, Maria
    Masala, Giovanna
    Pala, Valeria
    Tumino, Rosario
    Panico, Salvatore
    Peeters, Petra H
    Skeie, Guri
    Merino, Susana
    Duell, Eric J
    Rodríguez-Barranco, Miguel
    Dorronsoro, Miren
    Chirlaque, Maria-Dolores
    Ardanaz, Eva
    Gylling, Björn
    Schneede, Jörn
    Ericson, Ulrika
    Sternby, Hanna
    Khaw, Kay-Tee
    Bradbury, Kathryn E
    Huybrechts, Inge
    Aune, Dagfinn
    Vineis, Paolo
    Slimani, Nadia
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    Type
    Article
    Language
    en
    
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    Title
    Dietary folate intake and pancreatic cancer risk: Results from the European Prospective Investigation into Cancer and Nutrition.
    Published in
    Int J Cancer 2019; 144(7):1511-21
    Publiekssamenvatting
    Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/d) compared with the lowest (<241 μg/d) was 0.81 (95% CI: 0.51, 1.31; Ptrend = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles (HR=4.42 (95% CI: 1.05, 18.62) for ≥353 μg/d vs. <241 μg/d, Ptrend = 0.01). Nonetheless, there was no significant interaction between smoking and dietary folate intake (Pinteraction = 0.99). We found no association between dietary folate intake and PC risk in this large European study. This article is protected by copyright. All rights reserved.
    DOI
    10.1002/ijc.31830
    PMID
    30178496
    URI
    http://hdl.handle.net/10029/622188
    ae974a485f413a2113503eed53cd6c53
    10.1002/ijc.31830
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