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dc.contributor.authorPark, Jin Young
dc.contributor.authorBueno-de-Mesquita, H Bas
dc.contributor.authorFerrari, Pietro
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorde Batlle, Jordi
dc.contributor.authorTjønneland, Anne
dc.contributor.authorKyro, Cecilie
dc.contributor.authorRebours, Vinciane
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorMancini, Francesca Romana
dc.contributor.authorKatzke, Verena
dc.contributor.authorKühn, Tilman
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLa Vecchia, Carlo
dc.contributor.authorKritikou, Maria
dc.contributor.authorMasala, Giovanna
dc.contributor.authorPala, Valeria
dc.contributor.authorTumino, Rosario
dc.contributor.authorPanico, Salvatore
dc.contributor.authorPeeters, Petra H
dc.contributor.authorSkeie, Guri
dc.contributor.authorMerino, Susana
dc.contributor.authorDuell, Eric J
dc.contributor.authorRodríguez-Barranco, Miguel
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorChirlaque, Maria-Dolores
dc.contributor.authorArdanaz, Eva
dc.contributor.authorGylling, Björn
dc.contributor.authorSchneede, Jörn
dc.contributor.authorEricson, Ulrika
dc.contributor.authorSternby, Hanna
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorBradbury, Kathryn E
dc.contributor.authorHuybrechts, Inge
dc.contributor.authorAune, Dagfinn
dc.contributor.authorVineis, Paolo
dc.contributor.authorSlimani, Nadia
dc.date.accessioned2018-10-15T08:43:52Z
dc.date.available2018-10-15T08:43:52Z
dc.date.issued2018-09-04
dc.identifier.citationDietary folate intake and pancreatic cancer risk: Results from the European Prospective Investigation into Cancer and Nutrition. 2018 Int. J. Canceren
dc.identifier.issn1097-0215
dc.identifier.pmid30178496
dc.identifier.doi10.1002/ijc.31830
dc.identifier.urihttp://hdl.handle.net/10029/622188
dc.description.abstractPancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/d) compared with the lowest (<241 μg/d) was 0.81 (95% CI: 0.51, 1.31; Ptrend = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles (HR=4.42 (95% CI: 1.05, 18.62) for ≥353 μg/d vs. <241 μg/d, Ptrend = 0.01). Nonetheless, there was no significant interaction between smoking and dietary folate intake (Pinteraction = 0.99). We found no association between dietary folate intake and PC risk in this large European study. This article is protected by copyright. All rights reserved.
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.titleDietary folate intake and pancreatic cancer risk: Results from the European Prospective Investigation into Cancer and Nutrition.en
dc.typeArticleen
dc.identifier.journalInt J Cancer 2019; 144(7):1511-21en
html.description.abstractPancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/d) compared with the lowest (<241 μg/d) was 0.81 (95% CI: 0.51, 1.31; Ptrend = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles (HR=4.42 (95% CI: 1.05, 18.62) for ≥353 μg/d vs. <241 μg/d, Ptrend = 0.01). Nonetheless, there was no significant interaction between smoking and dietary folate intake (Pinteraction = 0.99). We found no association between dietary folate intake and PC risk in this large European study. This article is protected by copyright. All rights reserved.


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