Genome Detective: An Automated System for Virus Identification from High-throughput sequencing data.
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Authors
Vilsker, MichaelMoosa, Yumna
Nooij, Sam
Fonseca, Vagner
Ghysens, Yoika
Dumon, Korneel
Pauwels, Raf
Alcantara, Luiz Carlos
Vanden Eynden, Ewout
Vandamme, Anne-Mieke
Deforche, Koen
de Oliveira, Tulio
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ArticleLanguage
en
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Genome Detective: An Automated System for Virus Identification from High-throughput sequencing data.Published in
Bioinformatics 2018; advance online publication (ahead of print)Publiekssamenvatting
Genome Detective is an easy to use web-based software application that assembles the genomes of viruses quickly and accurately. The application uses a novel alignment method that constructs genomes by reference-based linking of de-novo contigs by combining amino-acids and nucleotide scores. The software was optimized using synthetic datasets to represent the great diversity of virus genomes. The application was then validated with next generation sequencing data of hundreds of viruses. User time is minimal and it is limited to the time required to upload the data.PMID
30124794ae974a485f413a2113503eed53cd6c53
10.1093/bioinformatics/bty695
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