Differences in antigenic sites and other functional regions between genotype A and G mumps virus surface proteins.
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Van Gucht, Steven
Rota, Paul A
Binnendijk, Rob van
MetadataShow full item record
TitleDifferences in antigenic sites and other functional regions between genotype A and G mumps virus surface proteins.
Published inSci Rep 2018; 8(1):13337
PubliekssamenvattingThe surface proteins of the mumps virus, the fusion protein (F) and haemagglutinin-neuraminidase (HN), are key factors in mumps pathogenesis and are important targets for the immune response during mumps virus infection. We compared the predicted amino acid sequences of the F and HN genes from Dutch mumps virus samples from the pre-vaccine era (1957-1982) with mumps virus genotype G strains (from 2004 onwards). Genotype G is the most frequently detected mumps genotype in recent outbreaks in vaccinated communities, especially in Western Europe, the USA and Japan. Amino acid differences between the Jeryl Lynn vaccine strains (genotype A) and genotype G strains were predominantly located in known B-cell epitopes and in N-linked glycosylation sites on the HN protein. There were eight variable amino acid positions specific to genotype A or genotype G sequences in five known B-cell epitopes of the HN protein. These differences may account for the reported antigenic differences between Jeryl Lynn and genotype G strains. We also found amino acid differences in and near sites on the HN protein that have been reported to play a role in mumps virus pathogenesis. These differences may contribute to the occurrence of genotype G outbreaks in vaccinated communities.
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- Authors: Ivancic-Jelecki J, Santak M, Forcic D
- Issue date: 2008 Sep
- Cross-neutralization between three mumps viruses & mapping of haemagglutinin-neuraminidase (HN) epitopes.
- Authors: Vaidya SR, Dvivedi GM, Jadhav SM
- Issue date: 2016 Jan
- Mumps virus strains isolated in Croatia in 1998 and 2005: Genotyping and putative antigenic relatedness to vaccine strains.
- Authors: Santak M, Kosutić-Gulija T, Tesović G, Ljubin-Sternak S, Gjenero-Margan I, Betica-Radić L, Forcić D
- Issue date: 2006 May
- Assessment of one-dose mumps-containing vaccine effectiveness on wild-type genotype F mumps viruses circulating in mainland China.
- Authors: Cui A, Zhu Z, Mao N, Si Y, Ma Y, Hu Y, Deng X, Wang L, Zeng L, Zhang Y, Xu W
- Issue date: 2018 Sep 11
- [Comparison of genotype characteristics between the circulating mumps virus strain in Beijing area and the vaccine strain].
- Authors: Chen M, Zhang TG, Chen LJ, Wu J, Yang J, Zhang W
- Issue date: 2009 Nov