Respiratory syncytial virus (RSV) infects primary neonatal and adult natural killer cells and affects their anti-viral effector function.

van Erp, Elisabeth A; Feyaerts, Dorien; Duijst, Maxime; Mulder, H Lie; Wicht, Oliver; Luytjes, Willem; Ferwerda, Gerben; van Kasteren, Puck B

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Authors

van Erp, Elisabeth A
Feyaerts, Dorien
Duijst, Maxime
Mulder, H Lie
Wicht, Oliver
Luytjes, Willem
Ferwerda, Gerben
van Kasteren, Puck B

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Title

Respiratory syncytial virus (RSV) infects primary neonatal and adult natural killer cells and affects their anti-viral effector function.

Published in

J Infect Dis 2019; 219(5):723-33

Publiekssamenvatting

Respiratory syncytial virus (RSV) is a major cause of severe acute lower respiratory tract infections in infants. Natural killer (NK) cells are important anti-viral effector cells that likely encounter RSV in the presence of virus-specific (maternal) antibodies. Since NK cells potentially contribute to immunopathology, we investigated whether RSV affects their anti-viral effector functions.