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dc.contributor.authorHamers, Timo
dc.contributor.authorLegradi, Jessica
dc.contributor.authorZwart, Nick
dc.contributor.authorSmedes, Foppe
dc.contributor.authorde Weert, Jasperien
dc.contributor.authorvan den Brandhof, Evert-Jan
dc.contributor.authorvan de Meent, Dik
dc.contributor.authorde Zwart, Dick
dc.date.accessioned2018-11-20T09:24:25Z
dc.date.available2018-11-20T09:24:25Z
dc.date.issued2018-09-20
dc.identifier.citationTime-Integrative Passive sampling combined with TOxicity Profiling (TIPTOP): an effect-based strategy for cost-effective chemical water quality assessment. 2018, 64:48-59 Environ. Toxicol. Pharmacol.en
dc.identifier.issn1872-7077
dc.identifier.pmid30296657
dc.identifier.doi10.1016/j.etap.2018.09.005
dc.identifier.urihttp://hdl.handle.net/10029/622283
dc.description.abstractThis study aimed at demonstrating that effect-based monitoring with passive sampling followed by toxicity profiling is more protective and cost-effective than the current chemical water quality assessment strategy consisting of compound-by-compound chemical analysis of selected substances in grab samples. Passive samplers were deployed in the Dutch river delta and in WWTP effluents. Their extracts were tested in a battery of bioassays and chemically analyzed to obtain toxicity and chemical profiles, respectively. Chemical concentrations in water were retrieved from publicly available databases. Seven different strategies were used to interpret the chemical and toxicity profiles in terms of ecological risk. They all indicated that the river sampling locations were relatively clean. Chemical-based monitoring resulted for many substances in measurements below detection limit and could only explain <20% of the observed in vitro toxicity. Effect-based monitoring yielded more informative conclusions as it allowed for ranking the sampling sites and for estimating a margin-of-exposure towards chronic effect ranges. Effect-based monitoring was also cheaper and more cost-effective (i.e. yielding more information per euro spent). Based on its identified strengths, weaknesses, opportunities, and threats (SWOT), a future strategy for effect-based monitoring has been proposed.
dc.language.isoenen
dc.rightsArchived with thanks to Environmental toxicology and pharmacologyen
dc.titleTime-Integrative Passive sampling combined with TOxicity Profiling (TIPTOP): an effect-based strategy for cost-effective chemical water quality assessment.en
dc.typeArticleen
dc.identifier.journalEnviron Toxicol Pharmacol 2018; 64:48-59en
html.description.abstractThis study aimed at demonstrating that effect-based monitoring with passive sampling followed by toxicity profiling is more protective and cost-effective than the current chemical water quality assessment strategy consisting of compound-by-compound chemical analysis of selected substances in grab samples. Passive samplers were deployed in the Dutch river delta and in WWTP effluents. Their extracts were tested in a battery of bioassays and chemically analyzed to obtain toxicity and chemical profiles, respectively. Chemical concentrations in water were retrieved from publicly available databases. Seven different strategies were used to interpret the chemical and toxicity profiles in terms of ecological risk. They all indicated that the river sampling locations were relatively clean. Chemical-based monitoring resulted for many substances in measurements below detection limit and could only explain <20% of the observed in vitro toxicity. Effect-based monitoring yielded more informative conclusions as it allowed for ranking the sampling sites and for estimating a margin-of-exposure towards chronic effect ranges. Effect-based monitoring was also cheaper and more cost-effective (i.e. yielding more information per euro spent). Based on its identified strengths, weaknesses, opportunities, and threats (SWOT), a future strategy for effect-based monitoring has been proposed.


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