Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation.
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Authors
Brynildsrud, Ola BPepperell, Caitlin S
Suffys, Philip
Grandjean, Louis
Monteserin, Johana
Debech, Nadia
Bohlin, Jon
Alfsnes, Kristian
Pettersson, John O-H
Kirkeleite, Ingerid
Fandinho, Fatima
da Silva, Marcia Aparecida
Perdigao, Joao
Portugal, Isabel
Viveiros, Miguel
Clark, Taane
Caws, Maxine
Dunstan, Sarah
Thai, Phan Vuong Khac
Lopez, Beatriz
Ritacco, Viviana
Kitchen, Andrew
Brown, Tyler S
van Soolingen, Dick
O'Neill, Mary B
Holt, Kathryn E
Feil, Edward J
Mathema, Barun
Balloux, Francois
Eldholm, Vegard
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ArticleLanguage
en
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Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation.Published in
Sci Adv 2018; 4(10):eaat5869Publiekssamenvatting
On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.PMID
30345355ae974a485f413a2113503eed53cd6c53
10.1126/sciadv.aat5869
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Except where otherwise noted, this item's license is described as Archived with thanks to Science advances
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