Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsBrynildsrud, Ola B
Pepperell, Caitlin S
Pettersson, John O-H
da Silva, Marcia Aparecida
Thai, Phan Vuong Khac
Brown, Tyler S
van Soolingen, Dick
O'Neill, Mary B
Holt, Kathryn E
Feil, Edward J
MetadataShow full item record
TitleGlobal expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation.
Published inSci Adv 2018; 4(10):eaat5869
PubliekssamenvattingOn the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Archived with thanks to Science advances
- Lineage specific histories of Mycobacterium tuberculosis dispersal in Africa and Eurasia.
- Authors: O'Neill MB, Shockey A, Zarley A, Aylward W, Eldholm V, Kitchen A, Pepperell CS
- Issue date: 2019 Jul
- Changing patterns of human migrations shaped the global population structure of Mycobacterium tuberculosis in France.
- Authors: Barbier M, Dumitrescu O, Pichat C, Carret G, Ronnaux-Baron AS, Blasquez G, Godin-Benhaim C, Boisset S, Carricajo A, Jacomo V, Fredenucci I, Pérouse de Montclos M, Genestet C, Flandrois JP, Ader F, Supply P, Lina G, Wirth T, Rasigade JP
- Issue date: 2018 Apr 11
- [Population structure analysis of Mycobacterium tuberculosis Beijing family in Japan].
- Authors: Iwamoto T
- Issue date: 2009 Dec
- Molecular structure of Mycobacterium tuberculosis population in Russia and its interaction with neighboring countries.
- Authors: Mokrousov I
- Issue date: 2015 Mar
- Population Genomics of Mycobacterium tuberculosis in Ethiopia Contradicts the Virgin Soil Hypothesis for Human Tuberculosis in Sub-Saharan Africa.
- Authors: Comas I, Hailu E, Kiros T, Bekele S, Mekonnen W, Gumi B, Tschopp R, Ameni G, Hewinson RG, Robertson BD, Goig GA, Stucki D, Gagneux S, Aseffa A, Young D, Berg S
- Issue date: 2015 Dec 21