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dc.contributor.authorBrynildsrud, Ola B
dc.contributor.authorPepperell, Caitlin S
dc.contributor.authorSuffys, Philip
dc.contributor.authorGrandjean, Louis
dc.contributor.authorMonteserin, Johana
dc.contributor.authorDebech, Nadia
dc.contributor.authorBohlin, Jon
dc.contributor.authorAlfsnes, Kristian
dc.contributor.authorPettersson, John O-H
dc.contributor.authorKirkeleite, Ingerid
dc.contributor.authorFandinho, Fatima
dc.contributor.authorda Silva, Marcia Aparecida
dc.contributor.authorPerdigao, Joao
dc.contributor.authorPortugal, Isabel
dc.contributor.authorViveiros, Miguel
dc.contributor.authorClark, Taane
dc.contributor.authorCaws, Maxine
dc.contributor.authorDunstan, Sarah
dc.contributor.authorThai, Phan Vuong Khac
dc.contributor.authorLopez, Beatriz
dc.contributor.authorRitacco, Viviana
dc.contributor.authorKitchen, Andrew
dc.contributor.authorBrown, Tyler S
dc.contributor.authorvan Soolingen, Dick
dc.contributor.authorO'Neill, Mary B
dc.contributor.authorHolt, Kathryn E
dc.contributor.authorFeil, Edward J
dc.contributor.authorMathema, Barun
dc.contributor.authorBalloux, Francois
dc.contributor.authorEldholm, Vegard
dc.date.accessioned2018-11-20T12:22:12Z
dc.date.available2018-11-20T12:22:12Z
dc.date.issued2018-10
dc.identifier.citationGlobal expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation. 2018, 4 (10):eaat5869 Sci Adven
dc.identifier.issn2375-2548
dc.identifier.pmid30345355
dc.identifier.doi10.1126/sciadv.aat5869
dc.identifier.urihttp://hdl.handle.net/10029/622309
dc.description.abstractOn the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.
dc.language.isoenen
dc.rightsArchived with thanks to Science advancesen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleGlobal expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation.en
dc.typeArticleen
dc.identifier.journalSci Adv 2018; 4(10):eaat5869en
refterms.dateFOA2018-12-18T14:36:59Z
html.description.abstractOn the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.


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