The impact of influenza vaccination on infection, hospitalisation and mortality in the Netherlands between 2003 and 2015.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
TitleThe impact of influenza vaccination on infection, hospitalisation and mortality in the Netherlands between 2003 and 2015.
Published inEpidemics 2019; 26:77-85
PubliekssamenvattingInfluenza epidemics annually cause substantial morbidity and mortality. For this reason, vaccination is offered yearly to persons with an elevated risk for complications. Assessments of the impact of vaccination are, however, hampered by year-to-year variation in epidemic size and vaccine effectiveness. We estimate the impact of the current vaccination programme comparing simulations with vaccination to counterfactual simulations without vaccination. The simulations rely on an age- and risk-structured transmission model that tracks the build-up and loss of immunity over successive seasons, and that allows the vaccine match to vary between seasons. The model parameters are estimated with a particle Monte Carlo method and approximate Bayesian computation, using epidemiological data on vaccine effectiveness and epidemic size in the Netherlands over a period of 11 years. The number of infections, hospitalisations and deaths vary greatly between years because waning of immunity and vaccine match may differ every season, which is in line with observed variation in influenza epidemic sizes. At an overall coverage of 21%, vaccination has averted on average 13% (7.2-19%, 95% range) of infections, 24% (16-36%) of hospitalisations, and 35% (16-50%) of deaths. This suggests that vaccination is mainly effective in protecting vaccinees from infection rather than reducing transmission. As the Dutch population continues to grow and age, the vaccination programme is projected (up to 2025) to gain in impact, despite a decreasing infection attack rate.
The following license files are associated with this item:
- Creative Commons
- Vaccinating children against influenza increases variability in epidemic size.
- Authors: Backer JA, van Boven M, van der Hoek W, Wallinga J
- Issue date: 2019 Mar
- Impact of influenza vaccination programmes among the elderly population on primary care, Portugal, Spain and the Netherlands: 2015/16 to 2017/18 influenza seasons.
- Authors: Machado A, Mazagatos C, Dijkstra F, Kislaya I, Gherasim A, McDonald SA, Kissling E, Valenciano M, Meijer A, Hooiveld M, Nunes B, Larrauri A
- Issue date: 2019 Nov
- Deaths averted by influenza vaccination in the U.S. during the seasons 2005/06 through 2013/14.
- Authors: Foppa IM, Cheng PY, Reynolds SB, Shay DK, Carias C, Bresee JS, Kim IK, Gambhir M, Fry AM
- Issue date: 2015 Jun 12
- Cost-Effectiveness of Pediatric Influenza Vaccination in The Netherlands.
- Authors: de Boer PT, Nagy L, Dolk FCK, Wilschut JC, Pitman R, Postma MJ
- Issue date: 2021 Jan
- An evaluation and update of methods for estimating the number of influenza cases averted by vaccination in the United States.
- Authors: Tokars JI, Rolfes MA, Foppa IM, Reed C
- Issue date: 2018 Nov 19