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dc.contributor.authorBernal-Meléndez, Estefanía
dc.contributor.authorLacroix, Marie-Christine
dc.contributor.authorBouillaud, Pascaline
dc.contributor.authorCallebert, Jacques
dc.contributor.authorOlivier, Benoit
dc.contributor.authorPersuy, Marie-Annick
dc.contributor.authorDurieux, Didier
dc.contributor.authorRousseau-Ralliard, Delphine
dc.contributor.authorAioun, Josiane
dc.contributor.authorCassee, Flemming
dc.contributor.authorCouturier-Tarrade, Anne
dc.contributor.authorValentino, Sarah
dc.contributor.authorChavatte-Palmer, Pascale
dc.contributor.authorSchroeder, Henri
dc.contributor.authorBaly, Christine
dc.date.accessioned2019-02-19T07:42:59Z
dc.date.available2019-02-19T07:42:59Z
dc.date.issued2019-01-17
dc.identifier.issn1743-8977
dc.identifier.pmid30654819
dc.identifier.doi10.1186/s12989-018-0288-7
dc.identifier.urihttp://hdl.handle.net/10029/622796
dc.description.abstractAirborne pollution, especially from diesel exhaust (DE), is known to have a negative effect on the central nervous system in exposed human populations. However, the consequences of gestational exposure to DE on the fetal brain remain poorly explored, with various effects depending on the conditions of exposure, as well as little information on early developmental stages. We investigated the short-term effects of indirect DE exposure throughout gestation on the developing brain using a rabbit model. We analyzed fetal olfactory tissues at the end of gestation and tested behaviors relevant to pups' survival at birth. Pregnant dams were exposed by nose-only inhalation to either clean air or DE with a content of particles (DEP) adjusted to 1 mg/m At GD28, nano-sized particles were observed in cilia and cytoplasm of the olfactory sensory neurons in the olfactory mucosa and in the cytoplasm of periglomerular cells in the olfactory bulbs of exposed fetuses. Moreover, cellular and axonal hypertrophies were observed throughout olfactory tissues. Concomitantly, fetal serotoninergic and dopaminergic systems were affected in the olfactory bulbs. Moreover, the neuromodulatory homeostasis was disturbed in a sex-dependent manner in olfactory tissues. At birth, the olfactory sensitivity to 2MB2 was reduced in exposed PND2 pups. Gestational exposure to DE alters olfactory tissues and affects monoaminergic neurotransmission in fetuses' olfactory bulbs, resulting in an alteration of olfactory-based behaviors at birth. Considering the anatomical and functional continuum between the olfactory system and other brain structures, and due to the importance of monoamine neurotransmission in the plasticity of neural circuits, such alterations could participate to disturbances in higher integrative structures, with possible long-term neurobehavioral consequences.en_US
dc.language.isoenen_US
dc.subjectAirborne pollutionen_US
dc.subjectBulbar neurotransmitter disturbancesen_US
dc.subjectDiesel exhausten_US
dc.subjectGestational exposureen_US
dc.subjectNano-particulate matteren_US
dc.subjectOlfactory dysfunctionen_US
dc.subjectOlfactory toxicityen_US
dc.subjectOlfactory-based behavioren_US
dc.subjectPheromonal responseen_US
dc.titleRepeated gestational exposure to diesel engine exhaust affects the fetal olfactory system and alters olfactory-based behavior in rabbit offspring.en_US
dc.typeArticleen_US
dc.identifier.journalPart Fibre Toxicol 2019; 16(1):5en_US
dc.source.journaltitleParticle and fibre toxicology


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