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dc.contributor.authorVrieling, Alina
dc.contributor.authorBueno-De-Mesquita, H Bas
dc.contributor.authorRos, Martine M
dc.contributor.authorKampman, Ellen
dc.contributor.authorAben, Katja K
dc.contributor.authorBüchner, Frederike L
dc.contributor.authorJansen, Eugène H
dc.contributor.authorRoswall, Nina
dc.contributor.authorTjønneland, Anne
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorCadeau, Claire
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorWeikert, Steffen
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLagiou, Pagona
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorSieri, Sabina
dc.contributor.authorPalli, Domenico
dc.contributor.authorPanico, Salvatore
dc.contributor.authorPeeters, Petra H
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorSkeie, Guri
dc.contributor.authorJakszyn, Paula
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorArdanaz, Eva
dc.contributor.authorSánchez, María-José
dc.contributor.authorEhrnström, Roy
dc.contributor.authorMalm, Johan
dc.contributor.authorLjungberg, Börje
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nick J
dc.contributor.authorBrennan, Paul
dc.contributor.authorJohansson, Mattias
dc.contributor.authorRiboli, Elio
dc.contributor.authorKiemeney, Lambertus A
dc.date.accessioned2019-02-19T08:06:57Z
dc.date.available2019-02-19T08:06:57Z
dc.date.issued2019-01-29
dc.identifier.issn1097-0215
dc.identifier.pmid30694528
dc.identifier.doi10.1002/ijc.32165
dc.identifier.urihttp://hdl.handle.net/10029/622806
dc.description.abstractPublished associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case-control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre-diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell carcinomas of the bladder (UCC). A total of 824 patients with newly diagnosed UCC were matched with 824 cohort members. Serum folate, homocysteine, and vitamins B6 and B12 were measured. Odds ratios (OR) and 95% confidence intervals (CI) for total, aggressive, and non-aggressive UCC were estimated using conditional logistic regression with adjustment for smoking status, smoking duration and intensity, and other potential confounders. Additionally, statistical interaction with smoking status was assessed. A halving in serum folate concentrations was moderately associated with risk of UCC (OR: 1.18; 95% CI: 0.98-1.43), in particular aggressive UCC (OR: 1.34; 95% CI: 1.02-1.75; p-heterogeneity = 0.19). Compared to never smokers in the highest quartile of folate concentrations, this association seemed only apparent among current smokers in the lowest quartile of folate concentrations (OR: 6.26; 95% CI: 3.62-10.81, p-interaction = 0.07). Dietary folate was not associated with aggressive UCC (OR: 1.26; 95% CI: 0.81-1.95; p-heterogeneity = 0.14). No association was observed between serum homocysteine, vitamins B6 and B12 and risk of UCC. This study suggests that lower serum folate concentrations are associated with increased UCC risk, in particular aggressive UCC. Residual confounding by smoking cannot be ruled out and these findings require confirmation in future studies with multiple measurements.en_US
dc.language.isoenen_US
dc.subjectB-vitaminsen_US
dc.subjectbiomarkeren_US
dc.subjectfolateen_US
dc.subjectnested case-controlen_US
dc.subjecturothelial cell carcinomasen_US
dc.titleOne-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition.en_US
dc.typeArticleen_US
dc.identifier.journalInt J Cancer 2019; advance online publication (ahead of print)en_US
dc.source.journaltitleInternational journal of cancer


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