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dc.contributor.authorPennings, Jeroen L A
dc.contributor.authorMariman, Rob
dc.contributor.authorHodemaekers, Hennie M
dc.contributor.authorReemers, Sylvia S N
dc.contributor.authorJanssen, Riny
dc.contributor.authorGuichelaar, Teun
dc.date.accessioned2019-02-19T08:54:41Z
dc.date.available2019-02-19T08:54:41Z
dc.date.issued2018-11-09
dc.identifier.issn2045-2322
dc.identifier.pmid30413794
dc.identifier.doi10.1038/s41598-018-35180-2
dc.identifier.urihttp://hdl.handle.net/10029/622814
dc.description.abstractAging poses an increased risk of severe infection by respiratory syncytial virus (RSV). The many different biological pathways comprising the response to infection in lungs that are influenced by aging are complex and remain to be defined more thoroughly. Towards finding new directions in research on aging, we aimed to define biological pathways in the acute response to RSV that are affected in the lungs by aging. We therefore profiled the full transcriptome of lung tissue of mice prior to and during RSV infection both at young and old age. In the absence of RSV, we found aging to downregulate genes that are involved in constitution of the extracellular matrix. Moreover, uninfected old mice showed elevated expression of pathways that resemble injury, metabolic aberrations, and disorders mediated by functions of the immune system that were induced at young age only by an exogenous trigger like RSV. Furthermore, infection by RSV mounted stronger activation of anti-viral type-I interferon pathways at old age. Despite such exaggerated anti-viral responses, old mice showed reduced control of virus. Altogether, our findings emphasize important roles in aging-related susceptibility to respiratory disease for extracellular matrix dysfunctions and dysregulated immune activation in lungs.en_US
dc.language.isoenen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.titleTranscriptomics in lung tissue upon respiratory syncytial virus infection reveals aging as important modulator of immune activation and matrix maintenance.en_US
dc.typeArticleen_US
dc.identifier.journalSci Rep 2018; 8(1):16653en_US
dc.source.journaltitleScientific reports
refterms.dateFOA2019-02-19T08:54:43Z


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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States