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dc.contributor.authorCostas, Laura
dc.contributor.authorLujan-Barroso, Leila
dc.contributor.authorBenavente, Yolanda
dc.contributor.authorAllen, Naomi E
dc.contributor.authorAmiano, Pilar
dc.contributor.authorArdanaz, Eva
dc.contributor.authorBesson, Caroline
dc.contributor.authorBoeing, Heiner
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorCervenka, Iris
dc.contributor.authorFortner, Renée T
dc.contributor.authorFournier, Agnès
dc.contributor.authorGunter, Marc
dc.contributor.authorHarlid, Sophia
dc.contributor.authorHuerta, José María
dc.contributor.authorJerkeman, Mats
dc.contributor.authorJirström, Karin
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKarakatsani, Anna
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorKotanidou, Anastasia
dc.contributor.authorLund, Eiliv
dc.contributor.authorMasala, Giovanna
dc.contributor.authorMattiello, Amalia
dc.contributor.authorMelin, Beatrice
dc.contributor.authorMenéndez, Virginia
dc.contributor.authorMurphy, Neil
dc.contributor.authorNieters, Alexandra
dc.contributor.authorOvervad, Kim
dc.contributor.authorRiboli, Elio
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorSánchez, Maria-Jose
dc.contributor.authorSchmidt, Julie A
dc.contributor.authorSieri, Sabina
dc.contributor.authorTjønneland, Anne
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorTumino, Rosario
dc.contributor.authorVermeulen, Roel
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorde Sanjosé, Silvia
dc.contributor.authorAgudo, Antonio
dc.contributor.authorCasabonne, Delphine
dc.date.accessioned2019-02-26T12:05:15Z
dc.date.available2019-02-26T12:05:15Z
dc.date.issued2019-02-01
dc.identifier.issn1476-6256
dc.identifier.pmid30481275
dc.identifier.doi10.1093/aje/kwy259
dc.identifier.urihttp://hdl.handle.net/10029/622837
dc.description.abstractThe role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992-2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use, or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had undergone surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) than women with natural menopause (hazard ratio = 1.51, 95% confidence interval: 1.17, 1.94). Given that this result may have been due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis.en_US
dc.language.isoenen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.titleReproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition.en_US
dc.typeArticleen_US
dc.identifier.journalAm J Epidemiol 2019; 188(2):274-81en_US
dc.source.journaltitleAmerican journal of epidemiology


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