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dc.contributor.authorLoef, Bette
dc.contributor.authorvan Baarle, Debbie
dc.contributor.authorvan der Beek, Allard J
dc.contributor.authorSanders, Elisabeth A M
dc.contributor.authorBruijning-Verhagen, Patricia
dc.contributor.authorProper, Karin I
dc.date.accessioned20200413
dc.date.available2019-02-26T12:12:39Z
dc.date.issued2018-11-26
dc.identifier.issn1476-6256
dc.identifier.pmid30475977
dc.identifier.doi10.1093/aje/kwy258
dc.identifier.urihttp://hdl.handle.net/10029/622839
dc.description.abstractRecently, there has been interest in whether shift work may enhance infection susceptibility. Our aim was to determine whether shift workers in healthcare have a higher incidence, duration, and severity of influenza-like illness (ILI) and acute respiratory illness (ARI) than non-shift workers. From September 2016-June 2017, 501 rotating and/or night shift workers and 88 non-shift workers from the Klokwerk+ study (2016-2017) daily registered occurrence of ILI/ARI symptoms using a smartphone application. Incidence rate of ILI/ARI episodes (defined as ≥2 symptoms on the same day/≥1 symptom during two consecutive days), mean duration per episode, and incidence rate of severe episodes were compared between shift and non-shift workers using negative binomial regression and linear mixed model analysis. In total, participants completed 110,347 diaries. Shift workers' incidence rate of ILI/ARI episodes was 1.20 (95%-CI:1.01, 1.43) times higher, and for severe ILI/ARI episodes 1.22 (95%-CI:1.01, 1.49) times higher, compared to non-shift workers. Mean duration per ILI/ARI episode did not differ (ratio between means=1.02 (95%-CI:0.87, 1.19)). In conclusion, shift workers in healthcare had more and more severe ILI/ARI episodes than non-shift workers, but with a similar duration. Insight into underlying mechanisms connecting shift work and infection susceptibility will contribute to the design of preventive initiatives.en_US
dc.language.isoenen_US
dc.titleShift Work and Respiratory Infections in Healthcare Workers.en_US
dc.typeArticleen_US
dc.identifier.journalAm J Epidemiol 2019; 188(3):509-17en_US
dc.source.journaltitleAmerican journal of epidemiology


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