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dc.contributor.authorvan Roeden, S E
dc.contributor.authorWever, P C
dc.contributor.authorKampschreur, L M
dc.contributor.authorGruteke, P
dc.contributor.authorVan Der Hoek, W
dc.contributor.authorHoepelman, A I M
dc.contributor.authorBleeker-Rovers, C P
dc.contributor.authorOosterheert, J J
dc.date.accessioned2019-03-05T11:24:27Z
dc.date.available2019-03-05T11:24:27Z
dc.date.issued2018-12-10
dc.identifier.issn1469-0691
dc.identifier.pmid30543852
dc.identifier.doi10.1016/j.cmi.2018.11.023
dc.identifier.urihttp://hdl.handle.net/10029/622868
dc.description.abstractChronic infection with Coxiella burnetii (chronic Q fever) can cause life-threatening conditions such as endocarditis, infected vascular prostheses, and infected arterial aneurysms. We aimed to assess prognosis of chronic Q fever patients in terms of complications and mortality. A large cohort of chronic Q fever patients was assessed to describe complications, overall mortality and chronic Q fever-related mortality. Chronic Q fever-related mortality was expressed as a case fatality rate (number of chronic Q fever-related deaths/number of chronic Q fever patients). Complications occurred in 166 of 439 (38%) chronic Q fever patients: in 61% of proven (153/249), 15% of probable (11/74), and 2% of possible chronic Q fever patients (2/116). Most frequently observed complications were acute aneurysms (14%), heart failure (13%), and non-cardiac abscesses (10%). Overall mortality was 38% (94/249) for proven chronic Q fever patients (median follow-up 3.6 years) and 22% (16/74) for probable chronic Q fever patients (median follow-up 4.7 years). The case fatality rate was 25% for proven (63/249) chronic Q fever patients and 4% for probable (3/74) chronic Q fever patients. Overall survival was significantly lower in patients with complications, compared to those without complications (p <0.001). In chronic Q fever patients, complications occur frequently and contribute to the mortality rate. Patients with proven chronic Q fever have the highest risk of complications and chronic Q fever-related mortality. Prognosis for patients with possible chronic Q fever is favourable in terms of complications and mortality.en_US
dc.language.isoenen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectComplicationsen_US
dc.subjectCoxiella burnetiien_US
dc.subjectEndocarditisen_US
dc.subjectInfected vascular prosthesisen_US
dc.subjectMortalityen_US
dc.subjectMycotic aneurysmen_US
dc.subjectQ feveren_US
dc.titleChronic Q fever-related complications and mortality: data from a nationwide cohort.en_US
dc.typeArticleen_US
dc.identifier.journalClin Microbiol Infect 2019; advance online publication (ahead of print)en_US
dc.source.journaltitleClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases


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