Chronic Q fever-related complications and mortality: data from a nationwide cohort.
dc.contributor.author | van Roeden, S E | |
dc.contributor.author | Wever, P C | |
dc.contributor.author | Kampschreur, L M | |
dc.contributor.author | Gruteke, P | |
dc.contributor.author | Van Der Hoek, W | |
dc.contributor.author | Hoepelman, A I M | |
dc.contributor.author | Bleeker-Rovers, C P | |
dc.contributor.author | Oosterheert, J J | |
dc.date.accessioned | 2019-03-05T11:24:27Z | |
dc.date.available | 2019-03-05T11:24:27Z | |
dc.date.issued | 2018-12-10 | |
dc.identifier.issn | 1469-0691 | |
dc.identifier.pmid | 30543852 | |
dc.identifier.doi | 10.1016/j.cmi.2018.11.023 | |
dc.identifier.uri | http://hdl.handle.net/10029/622868 | |
dc.description.abstract | Chronic infection with Coxiella burnetii (chronic Q fever) can cause life-threatening conditions such as endocarditis, infected vascular prostheses, and infected arterial aneurysms. We aimed to assess prognosis of chronic Q fever patients in terms of complications and mortality. A large cohort of chronic Q fever patients was assessed to describe complications, overall mortality and chronic Q fever-related mortality. Chronic Q fever-related mortality was expressed as a case fatality rate (number of chronic Q fever-related deaths/number of chronic Q fever patients). Complications occurred in 166 of 439 (38%) chronic Q fever patients: in 61% of proven (153/249), 15% of probable (11/74), and 2% of possible chronic Q fever patients (2/116). Most frequently observed complications were acute aneurysms (14%), heart failure (13%), and non-cardiac abscesses (10%). Overall mortality was 38% (94/249) for proven chronic Q fever patients (median follow-up 3.6 years) and 22% (16/74) for probable chronic Q fever patients (median follow-up 4.7 years). The case fatality rate was 25% for proven (63/249) chronic Q fever patients and 4% for probable (3/74) chronic Q fever patients. Overall survival was significantly lower in patients with complications, compared to those without complications (p <0.001). In chronic Q fever patients, complications occur frequently and contribute to the mortality rate. Patients with proven chronic Q fever have the highest risk of complications and chronic Q fever-related mortality. Prognosis for patients with possible chronic Q fever is favourable in terms of complications and mortality. | en_US |
dc.language.iso | en | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Complications | en_US |
dc.subject | Coxiella burnetii | en_US |
dc.subject | Endocarditis | en_US |
dc.subject | Infected vascular prosthesis | en_US |
dc.subject | Mortality | en_US |
dc.subject | Mycotic aneurysm | en_US |
dc.subject | Q fever | en_US |
dc.title | Chronic Q fever-related complications and mortality: data from a nationwide cohort. | en_US |
dc.type | Article | en_US |
dc.identifier.journal | Clin Microbiol Infect 2019; advance online publication (ahead of print) | en_US |
dc.source.journaltitle | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases |