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dc.contributor.authorGasull, Magda
dc.contributor.authorPumarega, José
dc.contributor.authorKiviranta, Hannu
dc.contributor.authorRantakokko, Panu
dc.contributor.authorRaaschou-Nielsen, Ole
dc.contributor.authorBergdahl, Ingvar A
dc.contributor.authorSandanger, Torkjel Manning
dc.contributor.authorGoñi, Fernando
dc.contributor.authorCirera, Lluís
dc.contributor.authorDonat-Vargas, Carolina
dc.contributor.authorAlguacil, Juan
dc.contributor.authorIglesias, Mar
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOvervad, Kim
dc.contributor.authorMancini, Francesca Romana
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorJohnson, Theron
dc.contributor.authorKühn, Tilman
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorKarakatsani, Anna
dc.contributor.authorPeppa, Eleni
dc.contributor.authorPalli, Domenico
dc.contributor.authorPala, Valeria
dc.contributor.authorTumino, Rosario
dc.contributor.authorNaccarati, Alessio
dc.contributor.authorPanico, Salvatore
dc.contributor.authorVerschuren, Monique
dc.contributor.authorVermeulen, Roel
dc.contributor.authorRylander, Charlotta
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorRodríguez-Barranco, Miguel
dc.contributor.authorMolinuevo, Amaia
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorArdanaz, Eva
dc.contributor.authorSund, Malin
dc.contributor.authorKey, Tim
dc.contributor.authorYe, Weimin
dc.contributor.authorJenab, Mazda
dc.contributor.authorMichaud, Dominique
dc.contributor.authorMatullo, Giuseppe
dc.contributor.authorCanzian, Federico
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorNieters, Alexandra
dc.contributor.authorNöthlings, Ute
dc.contributor.authorJeurnink, Suzanne
dc.contributor.authorChajes, Veronique
dc.contributor.authorMatejcic, Marco
dc.contributor.authorGunter, Marc
dc.contributor.authorAune, Dagfinn
dc.contributor.authorRiboli, Elio
dc.contributor.authorAgudo, Antoni
dc.contributor.authorGonzalez, Carlos Alberto
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorDuell, Eric J
dc.contributor.authorVineis, Paolo
dc.contributor.authorPorta, Miquel
dc.date.accessioned2019-03-14T12:39:43Z
dc.date.available2019-03-14T12:39:43Z
dc.date.issued2019-02-01
dc.identifier.issn1096-0953
dc.identifier.pmid30529143
dc.identifier.doi10.1016/j.envres.2018.11.027
dc.identifier.urihttp://hdl.handle.net/10029/622874
dc.description.abstractThe use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases. First, to summarize the main design features of a prospective case-control study -nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort- on plasma concentrations of persistent organic pollutants (POPs) and pancreatic cancer risk. And second, to assess the main methodological challenges posed by associations among characteristics and habits of study participants, fasting status, time from blood draw to cancer diagnosis, disease progression bias, basis of cancer diagnosis, and plasma concentrations of lipids and POPs. Results from etiologic analyses on POPs and pancreatic cancer risk, and other analyses, will be reported in future articles. Study subjects were 1533 participants (513 cases and 1020 controls matched by study centre, sex, age at blood collection, date and time of blood collection, and fasting status) enrolled between 1992 and 2000. Plasma concentrations of 22 POPs were measured by gas chromatography - triple quadrupole mass spectrometry (GC-MS/MS). To estimate the magnitude of the associations we calculated multivariate-adjusted odds ratios by unconditional logistic regression, and adjusted geometric means by General Linear Regression Models. There were differences among countries in subjects' characteristics (as age, gender, smoking, lipid and POP concentrations), and in study characteristics (as time from blood collection to index date, year of last follow-up, length of follow-up, basis of cancer diagnosis, and fasting status). Adjusting for centre and time of blood collection, no factors were significantly associated with fasting status. Plasma concentrations of lipids were related to age, body mass index, fasting, country, and smoking. We detected and quantified 16 of the 22 POPs in more than 90% of individuals. All 22 POPs were detected in some participants, and the smallest number of POPs detected in one person was 15 (median, 19) with few differences by country. The highest concentrations were found for p,p'-DDE, PCBs 153 and 180 (median concentration: 3371, 1023, and 810 pg/mL, respectively). We assessed the possible occurrence of disease progression bias (DPB) in eight situations defined by lipid and POP measurements, on one hand, and by four factors: interval from blood draw to index date, tumour subsite, tumour stage, and grade of differentiation, on the other. In seven of the eight situations results supported the absence of DPB.en_US
dc.language.isoenen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiomarkers, methodsen_US
dc.subjectDisease progression biasen_US
dc.subjectEnvironmental epidemiologyen_US
dc.subjectLipidsen_US
dc.subjectPancreatic canceren_US
dc.subjectPersistent organic pollutantsen_US
dc.titleMethodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort.en_US
dc.typeArticleen_US
dc.identifier.journalEnviron Res 2018; 169:417-33en_US
dc.source.journaltitleEnvironmental research


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