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dc.contributor.authorvan Erp, Elisabeth A
dc.contributor.authorvan Kampen, Mirjam R
dc.contributor.authorvan Kasteren, Puck B
dc.contributor.authorde Wit, Jelle
dc.date.accessioned2019-03-22T11:58:38Z
dc.date.available2019-03-22T11:58:38Z
dc.date.issued2019-03-12
dc.identifier.issn1999-4915
dc.identifier.pmid30870969
dc.identifier.doi10.3390/v11030243
dc.identifier.urihttp://hdl.handle.net/10029/622922
dc.description.abstractNatural killer (NK) cells are essential in the early immune response against viral infections, in particular through clearance of virus-infected cells. In return, viruses have evolved multiple mechanisms to evade NK cell-mediated viral clearance. Several unrelated viruses, including influenza virus, respiratory syncytial virus, and human immunodeficiency virus, can directly interfere with NK cell functioning through infection of these cells. Viral infection can lead to immune suppression, either by downregulation of the cytotoxic function or by triggering apoptosis, leading to depletion of NK cells. In contrast, some viruses induce proliferation or changes in the morphology of NK cells. In this review article, we provide a comprehensive overview of the viruses that have been reported to infect NK cells, we discuss their mechanisms of entry, and describe the interference with NK cell effector function and phenotype. Finally, we discuss the contribution of virus-infected NK cells to viral load. The development of specific therapeutics, such as viral entry inhibitors, could benefit from an enhanced understanding of viral infection of NK cells, opening up possibilities for the prevention of NK cell infection.en_US
dc.language.isoenen_US
dc.subjectNK cellsen_US
dc.subjecteffector functionsen_US
dc.subjectimmune evasionen_US
dc.subjectinfectionen_US
dc.subjectreceptorsen_US
dc.subjectvirusen_US
dc.titleViral Infection of Human Natural Killer Cells.en_US
dc.typeArticleen_US
dc.identifier.journalViruses 2019; 11(3)":pii.E243en_US
dc.source.journaltitleViruses


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