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dc.contributor.authorReinink, Peter
dc.contributor.authorSouter, Michael N T
dc.contributor.authorCheng, Tan-Yun
dc.contributor.authorvan Gorkom, Tamara
dc.contributor.authorLenz, Stefanie
dc.contributor.authorKubler-Kielb, Joanna
dc.contributor.authorStrle, Klemen
dc.contributor.authorKremer, Kristin
dc.contributor.authorThijsen, Steven F T
dc.contributor.authorSteere, Allen C
dc.contributor.authorGodfrey, Dale I
dc.contributor.authorPellicci, Daniel G
dc.contributor.authorMoody, D Branch
dc.contributor.authorVan Rhijn, Ildiko
dc.date.accessioned2019-03-22T12:14:54Z
dc.date.available2019-03-22T12:14:54Z
dc.date.issued2019-03-10
dc.identifier.issn1521-4141
dc.identifier.pmid30854633
dc.identifier.doi10.1002/eji.201847949
dc.identifier.urihttp://hdl.handle.net/10029/622930
dc.description.abstractLyme disease is a common multisystem disease caused by infection with a tick-transmitted spirochete, Borrelia burgdorferi and related Borrelia species. The monoglycosylated diacylglycerol known as B. burgdorferi glycolipid II (BbGL-II) is a major target of antibodies in sera from infected individuals. Here, we show that CD1b presents BbGL-II to human T cells and that the TCR mediates the recognition. However, we did not detect increased frequency of CD1b-BbGL-II binding T cells in the peripheral blood of Lyme disease patients compared to controls. Unexpectedly, mapping the T cell specificity for BbGL-II-like molecules using tetramers and activation assays revealed a concomitant response to CD1b-expressing APCs in absence of BbGL-II. Further, among all major classes of self-lipid tested, BbGL-II responsive TCRs show strong cross-reactivity to diacylglycerol, a self-lipid antigen with structural similarities to BbGL-II. Extending prior work on MHC and CD1b, CD1c, and CD1d proteins, this study provides evidence for cross-reactive CD1b-restricted T cell responses to bacterial and self-antigens, and identifies chemically defined targets for future discovery of self and foreign antigen cross-reactive T cells.en_US
dc.language.isoenen_US
dc.subjectCD1ben_US
dc.subjectLyme diseaseen_US
dc.subjectT cellsen_US
dc.subjectantigen specificityen_US
dc.subjectlipid antigenen_US
dc.titleCD1b presents self and Borrelia burgdorferi diacylglycerols to human T cells.en_US
dc.typeArticleen_US
dc.identifier.journalEur J Immunol 2019; advance online publication (ahead of print)en_US
dc.source.journaltitleEuropean journal of immunology


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