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dc.contributor.authorBenet, Marta
dc.contributor.authorAlbang, Richard
dc.contributor.authorPinart, Mariona
dc.contributor.authorHohmann, Cynthia
dc.contributor.authorTischer, Christina G
dc.contributor.authorAnnesi-Maesano, Isabella
dc.contributor.authorBaïz, Nour
dc.contributor.authorBindslev-Jensen, Carsten
dc.contributor.authorLødrup Carlsen, Karin C
dc.contributor.authorCarlsen, Kai-Hakon
dc.contributor.authorCirugeda, Lourdes
dc.contributor.authorEller, Esben
dc.contributor.authorFantini, Maria Pia
dc.contributor.authorGehring, Ulrike
dc.contributor.authorGerhard, Beatrix
dc.contributor.authorGori, Davide
dc.contributor.authorHallner, Eva
dc.contributor.authorKull, Inger
dc.contributor.authorLenzi, Jacopo
dc.contributor.authorMcEachan, Rosemary
dc.contributor.authorMinina, Eleonora
dc.contributor.authorMomas, Isabelle
dc.contributor.authorNarduzzi, Silvia
dc.contributor.authorPetherick, Emily S
dc.contributor.authorPorta, Daniela
dc.contributor.authorRancière, Fanny
dc.contributor.authorStandl, Marie
dc.contributor.authorTorrent, Maties
dc.contributor.authorWijga, Alet H
dc.contributor.authorWright, John
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorGuerra, Stefano
dc.contributor.authorSunyer, Jordi
dc.contributor.authorKeil, Thomas
dc.contributor.authorBousquet, Jean
dc.contributor.authorMaier, Dieter
dc.contributor.authorAnto, Josep M
dc.contributor.authorGarcia-Aymerich, Judith
dc.date.accessioned2019-03-22T12:38:40Z
dc.date.available2019-03-22T12:38:40Z
dc.date.issued2019-02-01
dc.identifier.issn1476-6256
dc.identifier.pmid30351340
dc.identifier.doi10.1093/aje/kwy242
dc.identifier.urihttp://hdl.handle.net/10029/622940
dc.description.abstractThe numbers of international collaborations among birth cohort studies designed to better understand asthma and allergies have increased in the last several years. However, differences in definitions and methods preclude direct pooling of original data on individual participants. As part of the Mechanisms of the Development of Allergy (MeDALL) Project, we harmonized data from 14 birth cohort studies (each with 3-20 follow-up periods) carried out in 9 European countries during 1990-1998 or 2003-2009. The harmonization process followed 6 steps: 1) organization of the harmonization panel; 2) identification of variables relevant to MeDALL objectives (candidate variables); 3) proposal of a definition for each candidate variable (reference definition); 4) assessment of the compatibility of each cohort variable with its reference definition (inferential equivalence) and classification of this inferential equivalence as complete, partial, or impossible; 5) convocation of a workshop to agree on the reference definitions and classifications of inferential equivalence; and 6) preparation and delivery of data through a knowledge management portal. We agreed on 137 reference definitions. The inferential equivalence of 3,551 cohort variables to their corresponding reference definitions was classified as complete, partial, and impossible for 70%, 15%, and 15% of the variables, respectively. A harmonized database was delivered to MeDALL investigators. In asthma and allergy birth cohorts, the harmonization of data for pooled analyses is feasible, and high inferential comparability may be achieved. The MeDALL harmonization approach can be used in other collaborative projects.en_US
dc.language.isoenen_US
dc.rights
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleIntegrating Clinical and Epidemiologic Data on Allergic Diseases Across Birth Cohorts: A Harmonization Study in the Mechanisms of the Development of Allergy Project.en_US
dc.typeArticleen_US
dc.identifier.journalAm J Epidemiol 2019; 188(2):408-17en_US
dc.source.journaltitleAmerican journal of epidemiology


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