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dc.contributor.authorTulen, Anna Dolores
dc.contributor.authorVennema, Harry
dc.contributor.authorvan Pelt, Wilfrid
dc.contributor.authorFranz, Eelco
dc.contributor.authorHofhuis, Agnetha
dc.date.accessioned2019-03-22T13:00:49Z
dc.date.available2019-03-22T13:00:49Z
dc.date.issued2019-02-08
dc.identifier.issn1532-2742
dc.identifier.pmid30738918
dc.identifier.doi10.1016/j.jinf.2019.02.001
dc.identifier.urihttp://hdl.handle.net/10029/622951
dc.description.abstractA case-control study was performed (2015-2017) to identify risk factors for acute hepatitis E in the Netherlands. A questionnaire on potential sources of hepatitis E virus (HEV) exposure, health and socio-demographics was completed by 376 patients with acute hepatitis E, and 1534 controls matched for age, gender and region of residence. Traditional Dutch dry raw sausages of pork muscle meat, called "cervelaat", "snijworst", and "boerenmetworst" were reported by 72% of the patients, and 46% of controls (aOR 3.0; 95%CI 2.2-4.1), with a population attributable fraction (PAF) of 48%. Direct contact with pigs and working with a septic tank were strong risk factors (aOR 3.1; 95%CI 1.3-7.3 and aOR 6.9; 95%CI 1.2-40.8, respectively), with a low PAF (2% and 1%, respectively). Host risk factors were pre-existing liver disease (aOR 3.8; 95%CI 2.0-7.1), diabetes (aOR 2.1; 95%CI 1.4-3.2), immunosuppressive medication (aOR 2.5; 95%CI 1.5-4.1), and gastric acid inhibitors (aOR 2.3; 95%CI 1.7-3.1). Dry raw pork sausages were the major source of HEV infection among our study population. The prevalence and cause of HEV contamination in these pork muscle meat products require further investigation. Infrequently reported, yet strong risk factors were contact with pigs, or a septic tank.en_US
dc.language.isoenen_US
dc.subjectHepatitis E virusen_US
dc.subjectHost risk factorsen_US
dc.subjectRisk factorsen_US
dc.subjectTransmission routesen_US
dc.subjectZoonosesen_US
dc.titleA case-control study into risk factors for acute hepatitis E in the Netherlands, 2015-2017.en_US
dc.typeArticleen_US
dc.identifier.journalJ Infect 2019; pii.S0163-4453(19)30036-2en_US
dc.source.journaltitleThe Journal of infection


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