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dc.contributor.authorArcella, Davide
dc.contributor.authorBoobis, Alan
dc.contributor.authorCressey, Peter
dc.contributor.authorErdely, Holly
dc.contributor.authorFattori, Vittorio
dc.contributor.authorLeblanc, Jean-Charles
dc.contributor.authorLipp, Markus
dc.contributor.authorReuss, Rainer
dc.contributor.authorScheid, Stefan
dc.contributor.authorTritscher, Angelika
dc.contributor.authorvan der Velde-Koerts, Trijntje
dc.contributor.authorVerger, Philippe
dc.date.accessioned20200413
dc.date.available2019-04-08T07:45:51Z
dc.date.issued2019-03-28
dc.identifier.issn1547-6898
dc.identifier.pmid30919727
dc.identifier.doi10.1080/10408444.2019.1578729
dc.identifier.urihttp://hdl.handle.net/10029/623007
dc.description.abstractRisk assessments for pesticide and veterinary drug residues in food are performed respectively by the Joint FAO/WHO Expert Meeting on Pesticide Residues (JMPR) and the Joint FAO/WHO Expert Committee on Food Additives (JECFA). The models used by the two Committees to assess chronic dietary exposure are based on different data and assumptions which may be confusing, particularly for risk managers, when the same compound is used to treat plants and animals. This publication details the results of combined chronic dietary exposure assessments for eight compounds used both as pesticide and veterinary drugs. It compares the results from models in use by JMPR and JECFA with those from national estimates performed by 17 countries. Results show that the JECFA model is better reflecting less than lifetime dietary exposure by considering consumption of children and high consumers. The JMPR model is a suitable model for estimating average chronic (lifetime) exposure to residues present in widely and regularly consumed staple commodities. However, it is suitable neither for estimating children's exposure nor more generally for assessing less than lifetime dietary exposure. In order to select the appropriate exposure model related to the occurrence of adverse effects i.e. effects occurring over less-than-lifetime or effects occurring only over lifetime, this paper proposes criteria to match the toxicological profile of the compound and the appropriate exposure scenarios. These approaches will continue to be harmonized to ensure the most scientifically sound basis for the risk assessment for pesticides and veterinary drug residues and consequently for other chemicals in food.en_US
dc.language.isoenen_US
dc.subjectJECFAen_US
dc.subjectJMPRen_US
dc.subjectPesticideen_US
dc.subjectchronic exposureen_US
dc.subjectfood safetyen_US
dc.subjectless-than-lifetime exposureen_US
dc.subjectrisk assessmenten_US
dc.subjecttoxicological profileen_US
dc.subjectveterinary drugen_US
dc.titleHarmonized methodology to assess chronic dietary exposure to residues from compounds used as pesticide and veterinary drug.en_US
dc.typeArticleen_US
dc.identifier.journalCrit Rev Toxicol 2019; 49(1):1-10en_US
dc.source.journaltitleCritical reviews in toxicology


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