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dc.contributor.authorvan den Berg, S P H
dc.contributor.authorWarmink, K
dc.contributor.authorBorghans, J A M
dc.contributor.authorKnol, M J
dc.contributor.authorvan Baarle, D
dc.date.accessioned2019-04-26T07:44:00Z
dc.date.available2019-04-26T07:44:00Z
dc.date.issued2019-04-04
dc.identifier.issn1432-1831
dc.identifier.pmid30949763
dc.identifier.doi10.1007/s00430-019-00602-z
dc.identifier.urihttp://hdl.handle.net/10029/623024
dc.description.abstractLatent infection with cytomegalovirus (CMV) is thought to accelerate aging of the immune system. With age, influenza vaccine responses are impaired. Although several studies investigated the effect of CMV infection on antibody responses to influenza vaccination, this led to contradicting conclusions. Therefore, we investigated the relation between CMV infection and the antibody response to influenza vaccination by performing a systematic review and meta-analysis. All studies on the antibody response to influenza vaccination in association with CMV infection were included (n = 17). The following outcome variables were extracted: (a) the geometric mean titer pre-/post-vaccination ratio (GMR) per CMV serostatus group, and in addition (b) the percentage of subjects with a response per CMV serostatus group and (c) the association between influenza- and CMV-specific antibody titers. The influenza-specific GMR revealed no clear evidence for an effect of CMV seropositivity on the influenza vaccine response in young or old individuals. Meta-analysis of the response rate to influenza vaccination showed a non-significant trend towards a negative effect of CMV seropositivity. However, funnel plot analysis suggests that this is a consequence of publication bias. A weak negative association between CMV antibody titers and influenza antibody titers was reported in several studies, but associations could not be analyzed systematically due to the variety of outcome variables. In conclusion, by systematically integrating the available studies, we show that there is no unequivocal evidence that latent CMV infection affects the influenza antibody response to vaccination. Further studies, including the level of CMV antibodies, are required to settle on the potential influence of latent CMV infection on the influenza vaccine response.en_US
dc.language.isoenen_US
dc.subjectAgeen_US
dc.subjectAntibody responseen_US
dc.subjectCytomegalovirusen_US
dc.subjectImmunosenescenceen_US
dc.subjectInfluenzaen_US
dc.subjectVaccineen_US
dc.titleEffect of latent cytomegalovirus infection on the antibody response to influenza vaccination: a systematic review and meta-analysis.en_US
dc.typeArticleen_US
dc.identifier.journalMed Microbiol Immunol 2019; advance online publication (ahead of print)en_US
dc.source.journaltitleMedical microbiology and immunology


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