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dc.contributor.authorBurgdorf, T
dc.contributor.authorPiersma, A H
dc.contributor.authorLandsiedel, R
dc.contributor.authorClewell, R
dc.contributor.authorKleinstreuer, N
dc.contributor.authorOelgeschläger, M
dc.contributor.authorDesprez, B
dc.contributor.authorKienhuis, A
dc.contributor.authorBos, P
dc.contributor.authorde Vries, R
dc.contributor.authorde Wit, L
dc.contributor.authorSeidle, T
dc.contributor.authorScheel, J
dc.contributor.authorSchönfelder, G
dc.contributor.authorvan Benthem, J
dc.contributor.authorVinggaard, A M
dc.contributor.authorEskes, C
dc.contributor.authorEzendam, J
dc.date.accessioned2019-04-26T07:45:52Z
dc.date.available2019-04-26T07:45:52Z
dc.date.issued2019-04-01
dc.identifier.issn1879-3177
dc.identifier.pmid30946968
dc.identifier.doi10.1016/j.tiv.2019.03.039
dc.identifier.urihttp://hdl.handle.net/10029/623025
dc.description.abstractAt a joint workshop organized by RIVM and BfR, international experts from governmental institutes, regulatory agencies, industry, academia and animal welfare organizations discussed and provided recommendations for the development, validation and implementation of innovative 3R approaches in regulatory toxicology. In particular, an evolutionary improvement of our current approach of test method validation in the context of defined approaches or integrated testing strategies was discussed together with a revolutionary approach based on a comprehensive description of the physiological responses of the human body to chemical exposure and the subsequent definition of relevant and predictive in vitro, in chemico or in silico methods. A more comprehensive evaluation of biological relevance, scientific validity and regulatory purpose of new test methods and assessment strategies together with case studies that provide practical experience with new approaches were discussed as essential steps to build up the necessary confidence to facilitate regulatory acceptance.en_US
dc.language.isoenen_US
dc.rightseu-repo/semantics/closedAccess
dc.subjectCase studiesen_US
dc.subjectEvolutionen_US
dc.subjectRelevanceen_US
dc.subjectRevolutionen_US
dc.subjectValidationen_US
dc.subjectWorkshopen_US
dc.titleWorkshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - Evolution versus revolution.en_US
dc.typeArticleen_US
dc.identifier.journalToxicol in Vitro 2019; 59:1-11en_US
dc.source.journaltitleToxicology in vitro : an international journal published in association with BIBRA


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