Early measles vaccination during an outbreak in The Netherlands: reduced short and long-term antibody responses in children vaccinated before 12 months of age.
dc.contributor.author | Brinkman, Iris D | |
dc.contributor.author | de Wit, Jelle | |
dc.contributor.author | Smits, Gaby P | |
dc.contributor.author | Ten Hulscher, Hinke I | |
dc.contributor.author | Jongerius, Maria C | |
dc.contributor.author | Abreu, Taymara C | |
dc.contributor.author | van der Klis, Fiona R M | |
dc.contributor.author | Hahné, Susan J M | |
dc.contributor.author | Koopmans, M P G | |
dc.contributor.author | Rots, Nynke Y | |
dc.contributor.author | van Baarle, Debbie | |
dc.contributor.author | van Binnendijk, Robert S | |
dc.date.accessioned | 2019-04-26T08:04:24Z | |
dc.date.available | 2019-04-26T08:04:24Z | |
dc.date.issued | 2019-04-11 | |
dc.identifier.issn | 1537-6613 | |
dc.identifier.pmid | 30972418 | |
dc.identifier.doi | 10.1093/infdis/jiz159 | |
dc.identifier.uri | http://hdl.handle.net/10029/623036 | |
dc.description.abstract | The majority of infants will not be protected by maternal antibodies until their first measles vaccination between 12-15 months of age. This provides incentive to reduce the age of measles vaccination, but immunological consequences are insufficiently understood and long-term effects are largely unknown. Infants who received early measles vaccination between 6-12 months and a second dose at 14 months of age (n=79) were compared with a control group who received one dose at 14 months of age (n=44). Measles-neutralizing antibody concentrations and avidity were determined up to 4 years of age. Infants with a first measles vaccination administered before 12 months of age show long-term reduced measles-neutralizing antibody concentrations and avidity compared to the control group. For 11.1% of children with a first dose before 9 months of age, antibody levels had dropped below the cutoff for clinical protection at 4 years of age. Early measles vaccination provides immediate protection in the majority of infants, but long-term neutralizing antibody responses are reduced compared to infants vaccinated at a later age. Additional vaccination at 14 months of age does not improve this. Long-term, this may result in an increasing number of children susceptible to measles. | en_US |
dc.language.iso | en | en_US |
dc.subject | antibody avidity | en_US |
dc.subject | antibody response | en_US |
dc.subject | protection | en_US |
dc.subject | timing of vaccination | en_US |
dc.title | Early measles vaccination during an outbreak in The Netherlands: reduced short and long-term antibody responses in children vaccinated before 12 months of age. | en_US |
dc.type | Article | en_US |
dc.identifier.journal | J Infect Dis 2019; advance online publication (ahead of print) | en_US |
dc.source.journaltitle | The Journal of infectious diseases |