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dc.contributor.authorBrinkman, Iris D
dc.contributor.authorde Wit, Jelle
dc.contributor.authorSmits, Gaby P
dc.contributor.authorTen Hulscher, Hinke I
dc.contributor.authorJongerius, Maria C
dc.contributor.authorAbreu, Taymara C
dc.contributor.authorvan der Klis, Fiona R M
dc.contributor.authorHahné, Susan J M
dc.contributor.authorKoopmans, M P G
dc.contributor.authorRots, Nynke Y
dc.contributor.authorvan Baarle, Debbie
dc.contributor.authorvan Binnendijk, Robert S
dc.date.accessioned2019-04-26T08:04:24Z
dc.date.available2019-04-26T08:04:24Z
dc.date.issued2019-04-11
dc.identifier.issn1537-6613
dc.identifier.pmid30972418
dc.identifier.doi10.1093/infdis/jiz159
dc.identifier.urihttp://hdl.handle.net/10029/623036
dc.description.abstractThe majority of infants will not be protected by maternal antibodies until their first measles vaccination between 12-15 months of age. This provides incentive to reduce the age of measles vaccination, but immunological consequences are insufficiently understood and long-term effects are largely unknown. Infants who received early measles vaccination between 6-12 months and a second dose at 14 months of age (n=79) were compared with a control group who received one dose at 14 months of age (n=44). Measles-neutralizing antibody concentrations and avidity were determined up to 4 years of age. Infants with a first measles vaccination administered before 12 months of age show long-term reduced measles-neutralizing antibody concentrations and avidity compared to the control group. For 11.1% of children with a first dose before 9 months of age, antibody levels had dropped below the cutoff for clinical protection at 4 years of age. Early measles vaccination provides immediate protection in the majority of infants, but long-term neutralizing antibody responses are reduced compared to infants vaccinated at a later age. Additional vaccination at 14 months of age does not improve this. Long-term, this may result in an increasing number of children susceptible to measles.en_US
dc.language.isoenen_US
dc.subjectantibody avidityen_US
dc.subjectantibody responseen_US
dc.subjectprotectionen_US
dc.subjecttiming of vaccinationen_US
dc.titleEarly measles vaccination during an outbreak in The Netherlands: reduced short and long-term antibody responses in children vaccinated before 12 months of age.en_US
dc.typeArticleen_US
dc.identifier.journalJ Infect Dis 2019; advance online publication (ahead of print)en_US
dc.source.journaltitleThe Journal of infectious diseases


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